Large Serrated Polyps Indicate a Greater Risk of Advanced Metachronous Colorectal Neoplasia than High-Grade Adenomas

Background: The risk of developing total metachronous advanced neoplasia (TMAN) in patients with index serrated lesions (SL) or adenoma with high-grade dysplasia (HGD) is unknown. We evaluated this risk in patients with either HGD, SL <10 mm or SL ≥10 mm at index colonoscopy, who underwent surveillance colonoscopies. Methods: This retrospective cohort study evaluated all consecutive patients (n = 2477) diagnosed between 2010 and 2019 with colorectal HGD, SL <10 mm or SL ≥10 mm. We excluded patients aged <45 or >75 years or those who had inflammatory bowel disease, hereditary colorectal cancer (CRC) syndromes, previous or synchronous CRC, or no follow-up colonoscopy. Descriptive variables were compared using analysis of variance or Pearson chi-squared tests. Multivariate Cox regressions were used to compare the risk of TMAN between the HGD, SL <10 mm and SL ≥10 mm groups. Results: Overall, 585 patients (mean age 63 years; 55% male; mean follow-up 3.67 years) were included (226 with SL <10 mm, 204 with SL ≥10 mm, 155 with HGD). Compared with SL <10 mm, patients with HGD did not have a significantly different rate of TMAN (HR=0.75 [0.39–1.44]) and patients with SL ≥10 mm had a higher rate of TMAN (HR=2.08 [1.38–3.15]). Compared with HGD, patients with SL ≥10 mm had a higher rate of TMAN (HR=1.87 [1.04–3.36]). The risk for TMAN was higher for patients with SL ≥10 mm than with HGD or SL <10 mm. This risk should be considered when planning surveillance intervals for patients diagnosed with large SLs.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Large Serrated Polyps Indicate a Greater Risk of Advanced Metachronous Colorectal Neoplasia than High-Grade Adenomas ; day:06 ; month:07 ; year:2023 ; Endoscopy International Open ; (06.07.2023)

Contributors, Places and Time

• Contributor: Medawar, Edgard ; Djinbachian, Roupen ; Taghiakbari, Mahsa ; Khoury, Tommy ; Zoughlami, Amine ; Zarandi-Nowroozi, Melissa ; Safih, Widad ; von Renteln, Daniel

Further information

• DOI: 10.1055/a-2124-9788
• URN: urn:nbn:de:101:1-2023082410244757705430
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:49 AM CEST