Characterization of Differentially Expressed miRNAs by CXCL12/SDF-1 in Human Bone Marrow Stromal Cells
Abstract: Stromal cell-derived factor 1 (SDF-1) is known to influence bone marrow stromal cell (BMSC) migration, osteogenic differentiation, and fracture healing. We hypothesize that SDF-1 mediates some of its effects on BMSCs through epigenetic regulation, specifically via microRNAs (miRNAs). MiRNAs are small non-coding RNAs that target specific mRNA and prevent their translation. We performed global miRNA analysis and determined several miRNAs were differentially expressed in response to SDF-1 treatment. Gene Expression Omnibus (GEO) dataset analysis showed that these miRNAs play an important role in osteogenic differentiation and fracture healing. KEGG and GO analysis indicated that SDF-1 dependent miRNAs changes affect multiple cellular pathways, including fatty acid biosynthesis, thyroid hormone signaling, and mucin-type O-glycan biosynthesis pathways. Furthermore, bioinformatics analysis showed several miRNAs target genes related to stem cell migration and differentiation. This study's findings indicated that SDF-1 induces some of its effects on BMSCs function through miRNA regulation.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Characterization of Differentially Expressed miRNAs by CXCL12/SDF-1 in Human Bone Marrow Stromal Cells ; volume:12 ; number:1 ; year:2021 ; pages:132-143 ; extent:12
Biomolecular concepts ; 12, Heft 1 (2021), 132-143 (gesamt 12)
- Urheber
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Potter, Matthew L.
Smith, Kathryn
Vyavahare, Sagar
Kumar, Sandeep
Periyasamy-Thandavan, Sudharsan
Hamrick, Mark
Isales, Carlos M.
Hill, William D.
Fulzele, Sadanand
- DOI
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10.1515/bmc-2021-0015
- URN
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urn:nbn:de:101:1-2409241647201.028692429522
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:36 MESZ
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Beteiligte
- Potter, Matthew L.
- Smith, Kathryn
- Vyavahare, Sagar
- Kumar, Sandeep
- Periyasamy-Thandavan, Sudharsan
- Hamrick, Mark
- Isales, Carlos M.
- Hill, William D.
- Fulzele, Sadanand
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