Association between Irritable Bowel Syndrome and Risk of Osteoporosis in Korean Premenopausal Women
Objective: The objective of this study is to evaluate irritable bowel syndrome (IBS) as a risk factor for osteoporosis and osteoporotic fracture in Korean women after controlling for basic confounding factors and considering detailed demographic and clinical information. Subjects and Methods: We performed a nationwide population-based retrospective cohort analysis and matched every IBS case with a non-IBS case at a 1:4 frequency ratio based on age. The population consisted of female patients with data in the Health Insurance Review and Assessment (HIRA) database from 2002 to 2010. To determine the risk of osteoporosis and osteoporotic fracture in IBS and non-IBS patients, hazard ratios (HRs) with 95% confidence intervals (CI) were estimated using Cox proportional hazards regression models, adjusting for confounding variables, such as the area of residence, health insurance type, and economic status. Results: We identified 1,017,468 patients in the HIRA database with data from 2002 to 2010 who could potentially be included in the cohort. Among these, we identified 1,545 (11.4%) women (age >19 years) with newly diagnosed IBS (IBS group). Additionally, 6,180 patients without IBS and age-matched to the IBS group were selected. Cox modeling revealed that the crude HRs for osteoporosis and osteoporotic fractures in patients with IBS were 1.476 (95% CI, 1.241–1.754) and 1.427 (95% CI, 1.086–1.876), respectively. Conclusion: Our data showed an increased incidence of osteoporosis and osteoporotic fractures in women with IBS compared with age-matched controls.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Association between Irritable Bowel Syndrome and Risk of Osteoporosis in Korean Premenopausal Women ; volume:30 ; number:6 ; year:2021 ; pages:527-534 ; extent:8
Medical principles and practice ; 30, Heft 6 (2021), 527-534 (gesamt 8)
- Creator
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Lee, Sang-Yeoup
Hwang, Hye-Rim
Yi, Yu-Hyeon
Kim, Jin-Mi
Kim, Yun-Jin
Lee, Jeong-Gyu
Cho, Young-Hye
Tak, Young-Jin
Lee, Seung Hun
Park, Eun Ju
Lee, Youngin
- DOI
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10.1159/000517909
- URN
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urn:nbn:de:101:1-2021122223252269402575
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:29 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Lee, Sang-Yeoup
- Hwang, Hye-Rim
- Yi, Yu-Hyeon
- Kim, Jin-Mi
- Kim, Yun-Jin
- Lee, Jeong-Gyu
- Cho, Young-Hye
- Tak, Young-Jin
- Lee, Seung Hun
- Park, Eun Ju
- Lee, Youngin
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