Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities

Abstract: Liposomes have received tremendous attention as a class of versatile pharmaceutical vehicles of great potential over the past several decades. However, the application of liposomes encounters major challenges due to the knowledge gaps in their in vivo delivery process. Immunoglobulin M (IgM) displays both pervasiveness and complexity in regulating the biological functions as well as eliciting adverse effects of liposomes. Understanding, mitigating, and exploiting the duality of IgM are prerequisites for achieving various biomedical applications of liposomes. In this review, the intricate relationship between liposomes and their biological environments has been summarized, with an emphasis on the regulatory effects of IgM on in vivo performance of liposomes. Corresponding solutions have also been discussed to evade IgM‐mediated opsonization for safe and efficient drug delivery.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Interplay between Liposomes and IgM: Principles, Challenges, and Opportunities ; day:07 ; month:05 ; year:2023 ; extent:15
Advanced science ; (07.05.2023) (gesamt 15)

Urheber
Wang, Huan
Lin, Shiqi
Wu, Xiying
Jiang, Kuan
Lu, Huiping
Zhan, Changyou

DOI
10.1002/advs.202301777
URN
urn:nbn:de:101:1-2023050815101066415370
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 11:04 MESZ

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Beteiligte

  • Wang, Huan
  • Lin, Shiqi
  • Wu, Xiying
  • Jiang, Kuan
  • Lu, Huiping
  • Zhan, Changyou

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