Sterically Demanding Flexible Phosphoric Acids for Constructing Efficient and Multi‐Purpose Asymmetric Organocatalysts
Abstract: Herein, we present a novel approach for various asymmetric transformations of cyclic enones. The combination of readily accessible chiral diamines and sterically demanding flexible phosphoric acids resulted in a simple and highly tunable catalyst framework. The careful optimization of the catalyst components led to the identification of a particularly powerful and multi‐purpose organocatalyst, which was successfully applied for asymmetric epoxidations, aziridinations, aza‐Michael‐initiated cyclizations, as well as for a novel Robinson‐like Michael‐initiated ring closure/aldol cyclization. High catalytic activities and excellent stereocontrol was observed for all four reaction types, indicating the excellent versatility of our catalytic system. Furthermore, a simple change in the diamine's configuration provided easy access to both product antipodes in all cases.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Sterically Demanding Flexible Phosphoric Acids for Constructing Efficient and Multi‐Purpose Asymmetric Organocatalysts ; day:26 ; month:04 ; year:2022 ; extent:1
Angewandte Chemie / International edition. International edition ; (26.04.2022) (gesamt 1)
- Creator
- DOI
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10.1002/anie.202202189
- URN
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urn:nbn:de:101:1-2022042715080592082645
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:25 AM CEST
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Associated
Other Objects (12)
Sterically Demanding Flexible Phosphoric Acids for Constructing Efficient and Multi‐Purpose Asymmetric Organocatalysts
The highly sterically demanding CpBIG
The highly sterically demanding CpBIG
C–C Coupling in sterically demanding porphyrin environments
Hydroalumination versus Deprotonation of Alkynes with Sterically Demanding Substituents
Electronic modification of a sterically demanding anionic pyridine ligand
Electronic Modification of a Sterically Demanding Anionic Pyridine Ligand
Synthesis of 1,3-cis-disubstituted sterically encumbered imidazolidinone organocatalysts
Isolation and Reactivity of Silepins with a Sterically Demanding Silyl Ligand
Polyphosphorus Compounds Derived from P 4 Conversion with Sterically Demanding Cobalt Complexes
Enhanced quantum yields by sterically demanding aryl-substituted β-diketonate ancillary ligands
Synthesis and Coordination Behavior of Polyphosphorus Complexes with Sterically Demanding Cp Ligands
Sterically Demanding Flexible Phosphoric Acids for Constructing Efficient and Multi‐Purpose Asymmetric Organocatalysts
The highly sterically demanding CpBIG
The highly sterically demanding CpBIG
C–C Coupling in sterically demanding porphyrin environments
Hydroalumination versus Deprotonation of Alkynes with Sterically Demanding Substituents
Electronic modification of a sterically demanding anionic pyridine ligand
Electronic Modification of a Sterically Demanding Anionic Pyridine Ligand
Synthesis of 1,3-cis-disubstituted sterically encumbered imidazolidinone organocatalysts
Isolation and Reactivity of Silepins with a Sterically Demanding Silyl Ligand
Polyphosphorus Compounds Derived from P 4 Conversion with Sterically Demanding Cobalt Complexes
Enhanced quantum yields by sterically demanding aryl-substituted β-diketonate ancillary ligands
Synthesis and Coordination Behavior of Polyphosphorus Complexes with Sterically Demanding Cp Ligands
Sterically Demanding Flexible Phosphoric Acids for Constructing Efficient and Multi‐Purpose Asymmetric Organocatalysts
The highly sterically demanding CpBIG
The highly sterically demanding CpBIG
C–C Coupling in sterically demanding porphyrin environments
Hydroalumination versus Deprotonation of Alkynes with Sterically Demanding Substituents
Electronic modification of a sterically demanding anionic pyridine ligand
Electronic Modification of a Sterically Demanding Anionic Pyridine Ligand
Synthesis of 1,3-cis-disubstituted sterically encumbered imidazolidinone organocatalysts
Isolation and Reactivity of Silepins with a Sterically Demanding Silyl Ligand
Polyphosphorus Compounds Derived from P 4 Conversion with Sterically Demanding Cobalt Complexes
Enhanced quantum yields by sterically demanding aryl-substituted β-diketonate ancillary ligands