iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties
Abstract: Antibodies are indispensable tools for biomedicine and anticancer therapy. Nevertheless, their use is compromised by high production costs, limited stability, and difficulty of chemical modification. The design and preparation of synthetic polymer conjugates capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, immunocytochemistry, and immunoprecipitation is reported. The conjugates, named “iBodies”, consist of an HPMA copolymer decorated with low‐molecular‐weight compounds that function as targeting ligands, affinity anchors, and imaging probes. We prepared specific conjugates targeting several proteins with known ligands and used these iBodies for enzyme inhibition, protein isolation, immobilization, quantification, and live‐cell imaging. Our data indicate that this highly modular and versatile polymer system can be used to produce inexpensive and stable antibody substitutes directed toward virtually any protein of interest with a known ligand.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties ; volume:55 ; number:7 ; year:2016 ; pages:2356-2360 ; extent:5
Angewandte Chemie / International edition. International edition ; 55, Heft 7 (2016), 2356-2360 (gesamt 5)
- Urheber
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Šácha, Pavel
Knedlík, Tomáš
Schimer, Jiří
Tykvart, Jan
Parolek, Jan
Navrátil, Václav
Dvořáková, Petra
Sedlák, František
Ulbrich, Karel
Strohalm, Jiří
Majer, Pavel
Šubr, Vladimír
Konvalinka, Jan
- DOI
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10.1002/anie.201508642
- URN
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urn:nbn:de:101:1-2022101407164902720842
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:31 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Šácha, Pavel
- Knedlík, Tomáš
- Schimer, Jiří
- Tykvart, Jan
- Parolek, Jan
- Navrátil, Václav
- Dvořáková, Petra
- Sedlák, František
- Ulbrich, Karel
- Strohalm, Jiří
- Majer, Pavel
- Šubr, Vladimír
- Konvalinka, Jan
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Nanostructured carbon materials decorated with organophosphorus moieties: synthesis and application
Chiral recognition of ephedrine: Hydrophilic polymers bearing β-cyclodextrin moieties as chiral sensitive host molecules
Thyroxine mimetics
Double-Hydrophilic Block Copolymers with Monophosphate Ester Moieties as Crystal Growth Modifiers of CaCO<sub>3</sub>
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Heterocyclic oligoamides as new peptide mimetics
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Decorated Teichmüller Theory
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