Chimeric antigen receptor–based therapies beyond cancer

Abstract: Adoptive cell transfer (ACT) therapies have gained renewed interest in the field of immunotherapy following the advent of chimeric antigen receptor (CAR) technology. This immunological breakthrough requires immune cell engineering with an artificial surface protein receptor for antigen‐specific recognition coupled to an intracellular protein domain for cell activating functions. CAR‐based ACT has successfully solved some hematological malignancies, and it is expected that other tumors may soon benefit from this approach. However, the potential of CAR technology is such that other immune‐mediated disorders are beginning to profit from it. This review will focus on CAR‐based ACT therapeutic areas other than oncology such as infection, allergy, autoimmunity, transplantation, and fibrotic repair. Herein, we discuss the results and limitations of preclinical and clinical studies in that regard.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Chimeric antigen receptor–based therapies beyond cancer ; day:06 ; month:02 ; year:2023 ; extent:11 ; European journal of immunology ; (06.02.2023) (gesamt 11)

Contributors, Places and Time

• Creator: Velasco‐de Andrés, María ; Muñoz‐Sánchez, Guillermo ; Carrillo‐Serradell, Laura ; Gutiérrez‐Hernández, María del Mar ; Català, Cristina ; Isamat, Marcos ; Lozano, Francisco

Further information

• DOI: 10.1002/eji.202250184
• URN: urn:nbn:de:101:1-2023020714035114077274
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:56 AM CEST