Convenient Synthesis of 2-Thioimidazolone/Menadione Conjugates via a Two-Step Sequence Starting with Direct Amination of Menadione
Abstract: A convenient route to conjugates of 2-thiohydantoins and menadione with linkers of various chemical nature through a two-stage reaction sequence (direct amination of the menadione with a functional amine followed by modification of a functional group) is presented. Optimal conditions for the direct amination of menadione using alkyl amines with substituents such as azide, alkyne, hydroxyl, amine, halogen, and carboxyl have been developed. Further modification of selected functionalities using CuAAC or esterification reactions with 2-thiohydantoines has been performed.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Convenient Synthesis of 2-Thioimidazolone/Menadione Conjugates via a Two-Step Sequence Starting with Direct Amination of Menadione ; volume:04 ; number:02 ; year:2020 ; pages:38-43
SynOpen ; 04, Heft 02 (2020), 38-43
- Beteiligte Personen und Organisationen
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Guk, Dmitry A.
Krasnovskaya, Olga O.
Zyk, Nikolai V.
Beloglazkina, Elena K.
- DOI
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10.1055/s-0040-1707519
- URN
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urn:nbn:de:101:1-2411072038540.917752186401
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:24 MESZ
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Beteiligte
- Guk, Dmitry A.
- Krasnovskaya, Olga O.
- Zyk, Nikolai V.
- Beloglazkina, Elena K.
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