The Relationship of Uremic Toxin Indoxyl Sulfate and Intestinal Elimination Mechanisms in Hemodialysis Patients

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Introduction: High indoxyl sulfate (IS) concentration is a serious problem for patients with CKD increasing the risk of cardiovascular diseases and CKD progression. Thus, the methods of decreasing the toxin concentrations are highly desired. The study aimed to discover the role of selected intestine-related factors on IS concentration. Methods: We evaluated the impact of ABCG2 and ABCC2 polymorphisms influencing activity and protein intake by normalized protein catabolic rate. Additionally, we examined the relation of IS and uric acid (UA) that can share common elimination transporters. A monocentric, prospective, open cohort pilot study was performed on 108 patients undergoing dialysis treatment. Results: The positive effect of residual diuresis on the reduction of IS levels was confirmed (p = 0.005). Also, an increase in IS depending on the dietary protein intake was confirmed (p = 0.040). No significant correlation between ABC gene polymorphisms was observed either, suggesting the negligible role of ABCG2 and ABCC2 in the elimination of IS in small bowel. The significant difference was observed for UA where ABCG2 421C>A (rs72552713) gene polymorphism was higher (505.3 μmol/L) in comparison with a wild-type genotype (360.5 μmol/L). Conclusion: No evidence of bowel elimination pathway via ABCC2 and ABCG2 transporters was found in renal replacement therapy patients.

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
The Relationship of Uremic Toxin Indoxyl Sulfate and Intestinal Elimination Mechanisms in Hemodialysis Patients ; volume:48 ; number:1 ; year:2022 ; pages:28-34 ; extent:7
Kidney & blood pressure research ; 48, Heft 1 (2022), 28-34 (gesamt 7)

Creator
Tomášová, Adéla
Tichá, Alena
Dusilová Sulková, Sylvie
Šafránek, Roman
Moučka, Petr
Chmelařová, Marcela
Baranová, Ivana
Párová, Helena
Nývltová, Zora
Štochlová, Karolína
Palička, Vladimír
Pavlíková, Ladislava
Zadák, Zdeněk
Hyšpler, Radomír

DOI
10.1159/000528130
URN
urn:nbn:de:101:1-2024010323595212146912
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:27 AM CEST

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Associated

  • Tomášová, Adéla
  • Tichá, Alena
  • Dusilová Sulková, Sylvie
  • Šafránek, Roman
  • Moučka, Petr
  • Chmelařová, Marcela
  • Baranová, Ivana
  • Párová, Helena
  • Nývltová, Zora
  • Štochlová, Karolína
  • Palička, Vladimír
  • Pavlíková, Ladislava
  • Zadák, Zdeněk
  • Hyšpler, Radomír

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