NUDT15 polymorphism explains serious toxicity to azathioprine in Indian patients with chronic immune thrombocytopenia and autoimmune hemolytic anemia: a case series

Objectives: Azathioprine (AZA) is a commonly used immunosuppressant in patients with autoimmune diseases. The toxic side effect to AZA (myelosuppression, hair loss, and oral ulcers) are highly unpredictable which can be life threatening if not identified earlier and dose adjustments made or the drug is withdrawn. Case presentation: Here we report a case series of five patients with severe toxicity while on treatment with AZA for autoimmune hemolytic anemia (n=1) and Immune thrombocytopenia (n=4). The common thiopurine methyltransferase (TPMT) variants (TPMT*2, *3A, *3B) were not present in these patients. However, all these patients had the NUDT15 415C>T variant that has been reported to explain serious toxicity to thioguanine in Asian patients. Conclusions: Our report suggests pre-emptive genotype-based dosing of AZA could reduce adverse toxicity and hence better outcome.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: NUDT15 polymorphism explains serious toxicity to azathioprine in Indian patients with chronic immune thrombocytopenia and autoimmune hemolytic anemia: a case series ; volume:35 ; number:4 ; year:2020 ; extent:04 ; Drug metabolism and drug interactions ; 35, Heft 4 (2020) (gesamt 04)

Beteiligte, Orts- und Zeitangaben

• Urheber: Devasia, Anup J. ; Illangeswaran, Raveen Stephen Stallon ; Raj, Infencia Xavier ; George, Biju ; Balasubramanian, Poonkuzhali

Weitere Informationen

• DOI: 10.1515/dmpt-2020-0128
• URN: urn:nbn:de:101:1-2412091457326.117969458154
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 05.08.0008, 15:36 MEZ