Click Chemistry and Targeted Degradation: A Winning Combination for Medicinal Chemists?
Abstract: Click chemistry is universally recognized as a powerful strategy for the fast and precise assembly of diverse building blocks. Targeted Protein Degradation (TPD) is a new therapeutic modality based on heterobifunctional small‐molecule degraders that provides new opportunities to medicinal chemists dealing with undruggable targets and incurable diseases. Here, we highlight how very recently the TPD field and that of click chemistry have merged, opening up the possibility for fine‐tuning the properties of a degrader, chemically assembled through a “click” synthesis. By reviewing concrete examples, we want to provide the reader with the insight that the application of click and bioorthogonal chemistry in the TDP field may be a winning combination.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Click Chemistry and Targeted Degradation: A Winning Combination for Medicinal Chemists? ; day:14 ; month:09 ; year:2023 ; extent:18
ChemMedChem ; (14.09.2023) (gesamt 18)
- Creator
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Pasieka, Anna
Diamanti, Eleonora
Uliassi, Elisa
Laura Bolognesi, Maria
- DOI
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10.1002/cmdc.202300422
- URN
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urn:nbn:de:101:1-2023091415182418071806
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:44 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Pasieka, Anna
- Diamanti, Eleonora
- Uliassi, Elisa
- Laura Bolognesi, Maria
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