Biochemical characterization of CRISPR-associated nucleases – what determines the specificity of Cas9?

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Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: Berlin, Humboldt-Universität zu Berlin, Dissertation, 2019

Classification: Naturwissenschaften

Event: Veröffentlichung

(where): Berlin

(who): Humboldt-Universität zu Berlin

(when): 2020

Creator: Bratovič, Majda

Contributor: Charpentier, Emmanuelle
Randau, Lennart
Brouns, Stan

DOI: 10.18452/21128

URN: urn:nbn:de:kobv:11-110-18452/21887-8

Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:48 AM CEST

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Associated

Bratovič, Majda
Charpentier, Emmanuelle
Randau, Lennart
Brouns, Stan
Humboldt-Universität zu Berlin

Time of origin

2020

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Biochemical characterization of CRISPR-associated nucleases – what determines the specificity of Cas9?

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Time of origin

Other Objects (12)

Genome engineering in mice using TALEN or CRISPR/Cas9 nucleases

Tracing the specificity of CRISPR-Cas nucleases in clinically relevant human cells

Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage

Directed evolution of CRISPR-Cas9 to increase its specificity

Eukaryotic-driven directed evolution of Cas9 nucleases

Mechanisms of the Specificity of the CRISPR/Cas9 System in Genome Editing

Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity

Detection of on-target and off-target mutations generated by CRISPR/Cas9 and other sequence-specific nucleases

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Genome-wide specificity of plant genome editing by both CRISPR–Cas9 and TALEN

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Tracing the specificity of CRISPR-Cas nucleases in clinically relevant human cells

Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage

Directed evolution of CRISPR-Cas9 to increase its specificity

Eukaryotic-driven directed evolution of Cas9 nucleases

Mechanisms of the Specificity of the CRISPR/Cas9 System in Genome Editing

Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity

Detection of on-target and off-target mutations generated by CRISPR/Cas9 and other sequence-specific nucleases

Biochemical characterization of Type VI CRISPR-associated nucleases

Genome-wide specificity of plant genome editing by both CRISPR–Cas9 and TALEN

CRISPR-Cas9 and T cells

CRISPR/Cas9 in Gastrointestinal Malignancies

Genome engineering in mice using TALEN or CRISPR/Cas9 nucleases

Tracing the specificity of CRISPR-Cas nucleases in clinically relevant human cells

Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage

Directed evolution of CRISPR-Cas9 to increase its specificity

Eukaryotic-driven directed evolution of Cas9 nucleases

Mechanisms of the Specificity of the CRISPR/Cas9 System in Genome Editing

Incorporation of bridged nucleic acids into CRISPR RNAs improves Cas9 endonuclease specificity

Detection of on-target and off-target mutations generated by CRISPR/Cas9 and other sequence-specific nucleases

Biochemical characterization of Type VI CRISPR-associated nucleases

Genome-wide specificity of plant genome editing by both CRISPR–Cas9 and TALEN

CRISPR-Cas9 and T cells

CRISPR/Cas9 in Gastrointestinal Malignancies

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