Reactive Oxygen Species‐Responsive Polymeric Prodrug Nanoparticles for Selective and Effective Treatment of Inflammatory Diseases
Abstract: It is challenging to manage inflammatory diseases using traditional anti‐inflammatory drugs due to their limited efficacy and systemic side effects, which are a result of their lack of selectivity, poor stability, and low solubility. Herein, it reports the development of a novel nanoparticle system, called ROS‐CA‐NPs, which is formed using polymer‐cinnamaldehyde (CA) conjugates and is responsive to reactive oxygen species (ROS). ROS‐CA‐NPs exhibit excellent drug stability, tissue selectivity, and controlled drug release upon oxidative stress activation. Using mouse models of chronic rheumatoid arthritis and acute ulcerative colitis, this study demonstrates that the systemic administration of ROS‐CA‐NPs results in their accumulation at inflamed lesions and leads to greater therapeutic efficacy compared to traditional drugs. Furthermore, ROS‐CA‐NPs present excellent biocompatibility. The findings suggest that ROS‐CA‐NPs have the potential to be developed as safe and effective nanotherapeutic agents for a broad range of inflammatory diseases.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Reactive Oxygen Species‐Responsive Polymeric Prodrug Nanoparticles for Selective and Effective Treatment of Inflammatory Diseases ; day:17 ; month:08 ; year:2023 ; extent:14
Advanced healthcare materials ; (17.08.2023) (gesamt 14)
- Creator
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Zhang, Yaming
Liu, Lu
Wang, Tianyi
Mao, Cong
Shan, Pengfei
Lau, Chak Sing
Li, Zhongyu
Guo, Weisheng
Wang, Weiping
- DOI
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10.1002/adhm.202301394
- URN
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urn:nbn:de:101:1-2023081815313793751962
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.20252025, 12:00 AM CEST
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Associated
- Zhang, Yaming
- Liu, Lu
- Wang, Tianyi
- Mao, Cong
- Shan, Pengfei
- Lau, Chak Sing
- Li, Zhongyu
- Guo, Weisheng
- Wang, Weiping
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