miR-539 mediates osteoblast mineralization by regulating Distal-less genes 2 in MC3T3-E1 cell line
Abstract: microRNAs (miRNAs) play an important role in osteoblast differentiation. However, the mechanisms of miRNAs regulating osteoblast mineralization still needs to be further cleared. Distal-less genes 2 (Dlx2) plays an important role in osteoblast differentiation. We have found that miR-539 was significantly downregulated and Dlx2 was found to be inversely correlated with miR-539 in MC3T3-E1 cell line during osteoblast mineralization. The overexpression of miR-539 significantly decreased the expression level of Dlx2 and suppressed the osteogenic marker gene expression level, alkaline phosphatase activity and matrix mineralization. Our study showed that miR-539 was a negative regulator in osteoblast mineralization and that the targeting of Dlx2 gene partly contributes to this inhibitory effect exerted by miR-539.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
miR-539 mediates osteoblast mineralization by regulating Distal-less genes 2 in MC3T3-E1 cell line ; volume:12 ; number:1 ; year:2017 ; pages:294-299 ; extent:6
Open life sciences ; 12, Heft 1 (2017), 294-299 (gesamt 6)
- Urheber
-
Han, Jianguo
Su, Li
Zhang, Chunyang
Jiang, Rongcai
- DOI
-
10.1515/biol-2017-0034
- URN
-
urn:nbn:de:101:1-2409201642440.021323152479
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:22 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Han, Jianguo
- Su, Li
- Zhang, Chunyang
- Jiang, Rongcai
Ähnliche Objekte (12)
Osteonectin bidirectionally regulates osteoblast mineralization
Zirconia Nanoparticles-Induced Toxic Effects in Osteoblast-Like 3T3-E1 Cells
Real-Time Vital Mineralization Detection and Quantification during In Vitro Osteoblast Differentiation
Water extract of Rumex crispus prevents bone loss by inhibiting osteoclastogenesis and inducing osteoblast mineralization
Resveratrol induces proliferation and differentiation of mouse pre-osteoblast MC3T3-E1 by promoting autophagy
MiR-135-5p promotes osteoblast differentiation by targeting HIF1AN in MC3T3-E1 cells
Cytotoxic and the proliferative effect of cuttlefish bone on MC3T3-E1 osteoblast cell line
![Human β-defensins [beta-defensins] differently affect proliferation, differentiation and mineralization of osteoblast-like MG63 cells](/assets/placeholder/searchResultMediaNoDigitisedMedia.png)
Human β-defensins [beta-defensins] differently affect proliferation, differentiation and mineralization of osteoblast-like MG63 cells
Variable osteogenic performance of MC3T3-E1 subclones impacts their utility as models of osteoblast biology
Astragaloside positively regulated osteogenic differentiation of pre-osteoblast MC3T3-E1 through PI3K/Akt signaling pathway
Loss of β ‐Actin Leads to Accelerated Mineralization and Dysregulation of Osteoblast‐Differentiation Genes during Osteogenic Reprogramming
Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells
Osteonectin bidirectionally regulates osteoblast mineralization
Zirconia Nanoparticles-Induced Toxic Effects in Osteoblast-Like 3T3-E1 Cells
Real-Time Vital Mineralization Detection and Quantification during In Vitro Osteoblast Differentiation
Water extract of Rumex crispus prevents bone loss by inhibiting osteoclastogenesis and inducing osteoblast mineralization
Resveratrol induces proliferation and differentiation of mouse pre-osteoblast MC3T3-E1 by promoting autophagy
MiR-135-5p promotes osteoblast differentiation by targeting HIF1AN in MC3T3-E1 cells
Cytotoxic and the proliferative effect of cuttlefish bone on MC3T3-E1 osteoblast cell line
Human β-defensins [beta-defensins] differently affect proliferation, differentiation and mineralization of osteoblast-like MG63 cells
Variable osteogenic performance of MC3T3-E1 subclones impacts their utility as models of osteoblast biology
Astragaloside positively regulated osteogenic differentiation of pre-osteoblast MC3T3-E1 through PI3K/Akt signaling pathway
Loss of β ‐Actin Leads to Accelerated Mineralization and Dysregulation of Osteoblast‐Differentiation Genes during Osteogenic Reprogramming
Adiponectin and AMP kinase activator stimulate proliferation, differentiation, and mineralization of osteoblastic MC3T3-E1 cells
Osteonectin bidirectionally regulates osteoblast mineralization
Zirconia Nanoparticles-Induced Toxic Effects in Osteoblast-Like 3T3-E1 Cells
Real-Time Vital Mineralization Detection and Quantification during In Vitro Osteoblast Differentiation
Water extract of Rumex crispus prevents bone loss by inhibiting osteoclastogenesis and inducing osteoblast mineralization
Resveratrol induces proliferation and differentiation of mouse pre-osteoblast MC3T3-E1 by promoting autophagy
MiR-135-5p promotes osteoblast differentiation by targeting HIF1AN in MC3T3-E1 cells
Cytotoxic and the proliferative effect of cuttlefish bone on MC3T3-E1 osteoblast cell line
Human β-defensins [beta-defensins] differently affect proliferation, differentiation and mineralization of osteoblast-like MG63 cells
Variable osteogenic performance of MC3T3-E1 subclones impacts their utility as models of osteoblast biology
Astragaloside positively regulated osteogenic differentiation of pre-osteoblast MC3T3-E1 through PI3K/Akt signaling pathway
Loss of β ‐Actin Leads to Accelerated Mineralization and Dysregulation of Osteoblast‐Differentiation Genes during Osteogenic Reprogramming