Quantitative Formation of Monomeric G‐Quadruplex DNA from Multimeric Structures of c‐Myc Promoter Sequence

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Abstract: G‐Quadruplex (G4)‐forming DNA sequences have a tendency to form stable multimeric structures. This can be problematic for studies with synthetic oligodeoxynucleotides. Herein, we describe a method that quantitatively converts multimeric intermolecular structures of the Pu27 sequence from the c‐myc promoter into the desired monomeric G4 by alkaline treatment and refolding.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Quantitative Formation of Monomeric G‐Quadruplex DNA from Multimeric Structures of c‐Myc Promoter Sequence ; volume:21 ; number:17 ; year:2020 ; pages:2445-2448 ; extent:4
ChemBioChem ; 21, Heft 17 (2020), 2445-2448 (gesamt 4)

Creator: Rauser, Valerie
Weinhold, Elmar

DOI: 10.1002/cbic.202000159

URN: urn:nbn:de:101:1-2022061905231747418595

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:36 AM CEST

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Associated

Rauser, Valerie
Weinhold, Elmar

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