Peptide-based vectors: recent developments
Abstract: Peptides and peptide-cargo complexes have been used for drug delivery and gene therapy. One of the most used delivery vectors are cell-penetrating peptides, due to their ability to be taken up by a variety of cell types and deliver a large variety of cargoes through the cell membrane with low cytotoxicity. In vitro and in vivo studies have shown their possibility and full effectiveness to deliver oligonucleotides, plasmid DNA, small interfering RNAs, antibodies, and drugs. We report in this review some of the latest strategies for peptide-mediated delivery of nucleic acids. It focuses on peptide-based vectors for therapeutic molecules and on nucleic acid delivery. In addition, we discuss recent applications and clinical trials.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Peptide-based vectors: recent developments ; volume:5 ; number:6 ; year:2014 ; pages:479-488 ; extent:10
Biomolecular concepts ; 5, Heft 6 (2014), 479-488 (gesamt 10)
- Creator
- DOI
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10.1515/bmc-2014-0024
- URN
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urn:nbn:de:101:1-2409241626145.248526596509
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:30 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Cerrato, Carmine Pasquale
- Lehto, Tõnis
- Langel, Ülo
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