Continuous flow synthesis of α-aryl-α-aminophosphonates
Abstract: The synthesis of α-aryl-α-aminophosphonates was performed by the three-component Kabachnik-Fields reaction of primary amines, benzaldehyde derivatives and dialkyl phosphites in a continuous flow microwave reactor. The target compounds could be obtained in high (~90%) yields without any catalyst in simple alcohols as the solvent. The flow process elaborated required shorter reaction times and lower excess of the reagent, as compared to the “traditional” batch reactions, and allowed the synthesis of the α-aminophosphonates on a somewhat larger scale.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Continuous flow synthesis of α-aryl-α-aminophosphonates ; volume:91 ; number:1 ; year:2019 ; pages:67-76 ; extent:10
Pure and applied chemistry ; 91, Heft 1 (2019), 67-76 (gesamt 10)
- Urheber
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Bálint, Erika
Tajti, Ádám
Ladányi-Pára, Katalin
Tóth, Nóra
Mátravölgyi, Béla
Keglevich, György
- DOI
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10.1515/pac-2018-0923
- URN
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urn:nbn:de:101:1-2024022313195437846066
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:50 MESZ
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Beteiligte
- Bálint, Erika
- Tajti, Ádám
- Ladányi-Pára, Katalin
- Tóth, Nóra
- Mátravölgyi, Béla
- Keglevich, György
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