Modulating the p53-MDM2 pathway : the therapeutic potential of natural compounds in cancer treatment
Abstract: The p53-MDM2 pathway plays a crucial role regulating tumor suppression and is a focal point of cancer research. This literature review delves into the complex interplay between the tumor suppressor protein p53 and its main regulator MDM2, highlighting their interaction and implications in cancer development and progression. The review compiles and summarizes the existing understanding of the biology and regulation of p53 and MDM2, emphasizing their roles in various cellular processes, including cell cycle regulation, DNA repair, apoptosis, and metabolism. It also discusses the disruption of the p53-MDM2 interaction in different cancer types and its impact on tumor progression and therapeutic resistance. Recent studies have highlighted natural products as promising avenues for targeting the p53-MDM2 pathway. This review categorizes these natural compounds into three groups based on their mechanisms: those that inhibit MDM2 expression or stability, those that prevent p53-MDM2 binding.... https://www.excli.de/excli/article/view/7791
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Modulating the p53-MDM2 pathway ; volume:23 ; year:2024
EXCLI journal ; 23 (2024)
- Urheber
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Ramli, Iman
Cheriet, Thamere
Posadino, Anna Maria
Giordo, Roberta
Fenu, Grazia
Chukwuemeka Nwachukwu, Kingsley
Adebayo Oyewole, Oluwafemi
Oluwaseun Adetunji, Charles
Calina, Daniela
Sharifi-Rad, Javad
Pintus, Gianfranco
- DOI
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10.17179/excli2024-7791
- URN
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urn:nbn:de:101:1-2501170213179.906433437987
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:27 MESZ
Datenpartner
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Beteiligte
- Ramli, Iman
- Cheriet, Thamere
- Posadino, Anna Maria
- Giordo, Roberta
- Fenu, Grazia
- Chukwuemeka Nwachukwu, Kingsley
- Adebayo Oyewole, Oluwafemi
- Oluwaseun Adetunji, Charles
- Calina, Daniela
- Sharifi-Rad, Javad
- Pintus, Gianfranco
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