Biodegradable Cationic and Ionizable Cationic Lipids: A Roadmap for Safer Pharmaceutical Excipients
Abstract: Cationic and ionizable cationic lipids are broadly applied as auxiliary agents, but their use is associated with adverse effects. If these excipients are rapidly degraded to endogenously occurring metabolites such as amino acids and fatty acids, their toxic potential can be minimized. So far, synthesized and evaluated biodegradable cationic and ionizable cationic lipids already showed promising results in terms of functionality and safety. Within this review, an overview about the different types of such biodegradable lipids, the available building blocks, their synthesis and cleavage by endogenous enzymes is provided. Moreover, the relationship between the structure of the lipids and their toxicity is described. Their application in drug delivery systems is critically discussed and placed in context with the lead compounds used in mRNA vaccines. Moreover, their use as preservatives is reviewed, guidance for their design is provided, and an outlook on future developments is given.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Biodegradable Cationic and Ionizable Cationic Lipids: A Roadmap for Safer Pharmaceutical Excipients ; day:06 ; month:01 ; year:2023 ; extent:24
Small ; (06.01.2023) (gesamt 24)
- Creator
-
Jörgensen, Arne Matteo
Wibel, Richard
Bernkop‐Schnürch, Andreas
- DOI
-
10.1002/smll.202206968
- URN
-
urn:nbn:de:101:1-2023010714114848068363
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
- 15.08.2025, 7:37 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Jörgensen, Arne Matteo
- Wibel, Richard
- Bernkop‐Schnürch, Andreas
Other Objects (12)
Permanently Charged Cationic Lipids—Evolution from Excipients to Therapeutic Lipids
Development of siRNA formulations based on cationic and biodegradable polymers
Multi‐Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors
Multi‐Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors
Cationic ring opening polymerization
Histidine-based ionizable cationic surfactants: novel biodegradable agents for hydrophilic macromolecular drug delivery
Biodegradable ether amines for reverse cationic flotation separation of ultrafine quartz from magnetite
Meeting at the Membrane – Confined Water at Cationic Lipids & Neuronal Growth on Fluid Lipid Bilayers : Meeting at the Membrane – Confined Water at Cationic Lipids &Neuronal Growth on Fluid Lipid Bilayers
The cationic polymerization of alkenylfurans
A Cationic NHC‐Supported Borole
IR spectra of cationic 1,5,9-triazacoronene and two of its cationic derivatives
In vivo gene silencing in the liver with siRNA loaded non-biodegradable and biodegradable cationic nanohydrogel particles for antifibrotic therapy
Permanently Charged Cationic Lipids—Evolution from Excipients to Therapeutic Lipids
Development of siRNA formulations based on cationic and biodegradable polymers
Multi‐Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors
Multi‐Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors
Cationic ring opening polymerization
Histidine-based ionizable cationic surfactants: novel biodegradable agents for hydrophilic macromolecular drug delivery
Biodegradable ether amines for reverse cationic flotation separation of ultrafine quartz from magnetite
Meeting at the Membrane – Confined Water at Cationic Lipids & Neuronal Growth on Fluid Lipid Bilayers : Meeting at the Membrane – Confined Water at Cationic Lipids &Neuronal Growth on Fluid Lipid Bilayers
The cationic polymerization of alkenylfurans
A Cationic NHC‐Supported Borole
IR spectra of cationic 1,5,9-triazacoronene and two of its cationic derivatives
In vivo gene silencing in the liver with siRNA loaded non-biodegradable and biodegradable cationic nanohydrogel particles for antifibrotic therapy
Permanently Charged Cationic Lipids—Evolution from Excipients to Therapeutic Lipids
Development of siRNA formulations based on cationic and biodegradable polymers
Multi‐Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors
Multi‐Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors
Cationic ring opening polymerization
Histidine-based ionizable cationic surfactants: novel biodegradable agents for hydrophilic macromolecular drug delivery
Biodegradable ether amines for reverse cationic flotation separation of ultrafine quartz from magnetite
Meeting at the Membrane – Confined Water at Cationic Lipids & Neuronal Growth on Fluid Lipid Bilayers : Meeting at the Membrane – Confined Water at Cationic Lipids &Neuronal Growth on Fluid Lipid Bilayers
The cationic polymerization of alkenylfurans
A Cationic NHC‐Supported Borole
IR spectra of cationic 1,5,9-triazacoronene and two of its cationic derivatives