A persistent prefrontal reference frame across time and task rules
Abstract: Behavior can be remarkably consistent, even over extended time periods, yet whether this is reflected in stable or ‘drifting’ neuronal responses to task features remains controversial. Here, we find a persistently active ensemble of neurons in the medial prefrontal cortex (mPFC) of mice that reliably maintains trajectory-specific tuning over several weeks while performing an olfaction-guided spatial memory task. This task-specific reference frame is stabilized during learning, upon which repeatedly active neurons show little representational drift and maintain their trajectory-specific tuning across long pauses in task exposure and across repeated changes in cue-target location pairings. These data thus suggest a ‘core ensemble’ of prefrontal neurons forming a reference frame of task-relevant space for the performance of consistent behavior over extended periods of time
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Nature Communications. - 15, 1 (2024) , 2115, ISSN: 2041-1723
- Klassifikation
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Medizin, Gesundheit
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2024
- Urheber
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Muysers, Hannah
Chen, Hung-Ling
Hahn, Johannes-Martin
Folschweiller, Shani
Sigurdsson, Torfi
Sauer, Jonas-Frederic
Bartos, Marlene
- DOI
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10.1038/s41467-024-46350-4
- URN
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urn:nbn:de:bsz:25-freidok-2463450
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 14.08.2025, 10:53 MESZ
Datenpartner
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Beteiligte
- Muysers, Hannah
- Chen, Hung-Ling
- Hahn, Johannes-Martin
- Folschweiller, Shani
- Sigurdsson, Torfi
- Sauer, Jonas-Frederic
- Bartos, Marlene
- Universität
Entstanden
- 2024
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