Estimation of the cost-effectiveness of apixaban versus vitamin K antagonists in the management of atrial fibrillation in Argentina

Artikel

Apixaban, a novel oral anticoagulant which has been approved for the prevention of stroke and systemic embolism in non-valvular atrial fibrillation, reduces both ischemic and haemorrhagic stroke and produces fewer bleedings than vitamin K antagonist warfarin. These clinical results lead to a decrease in health care resource utilization and, therefore, have a positive impact on health economics of atrial fibrillation. The cost-effectiveness of apixaban has been assessed in a variety of clinical settings and countries. However, data from emergent markets, as is the case of Argentina, are still scarce. We performed a cost-effectiveness analysis of apixaban versus warfarin in non-valvular atrial fibrillation (NVAF) in patients suitable for oral anticoagulation in Argentina. A Markov-based model including both costs and effects were used to simulate a cohort of patients with NVAF. Local epidemiological, resource utilization and cost data were used and all inputs were validated by a Delphi Panel of local experts. We adopted the payer's perspective with costs expressed in 2012 US Dollars. The study revealed that apixaban is cost-effective compared with warfarin using a willingness to pay threshold ranging from 1 to 3 per capita Gross Domestic Product (11558 - 34664 USD) with an incremental cost-effectiveness ratio of 786.08 USD per QALY gained. The benefit is primarily a result of the reduction in stroke and bleeding events. The study demonstrates that apixaban is a cost-effective alternative to warfarin in Argentina.

Object Details

• Language: Englisch

References and Relationships

• Bibliographic citation: Journal: Health Economics Review ; ISSN: 2191-1991 ; Volume: 5 ; Year: 2015 ; Issue: 17 ; Pages: 1-10 ; Heidelberg: Springer

Classification and Topics

• Classification: Wirtschaft
• Subject: Apixaban ; Warfarin ; Novel oral anticoagulants ; Cost-effectiveness

Contributors, Places and Time

• Event: Geistige Schöpfung
• (who): Giorgi, Mariano Anibal ; Caroli, Christian ; Giglio, Norberto Damian ; Micone, Paula ; Aiello, Eleonora ; Vulcano, Cristina ; Blanco, Julia ; Donato, Bonnie ; Quevedo, Joaquin Mould
• Event: Veröffentlichung
• (who): Springer
• (where): Heidelberg
• (when): 2015

Further information

• DOI: doi:10.1186/s13561-015-0052-8
• Handle: http://hdl.handle.net/10419/150497
• Last update: 10.03.2025, 11:46 AM CET