Sox9: A potential regulator of cancer stem cells in osteosarcoma
Abstract: Osteosarcoma is a highly aggressive bone tumor primarily affecting children and adolescents. Despite advancements in treatment modalities, the prognosis for osteosarcoma patients remains poor, emphasizing the need for a deeper understanding of its underlying mechanisms. In recent years, the concept of cancer stem cells (CSCs) has emerged as a crucial factor in tumor initiation, progression, and therapy resistance. These specialized subpopulations of cells possess self-renewal capacity, tumorigenic potential, and contribute to tumor heterogeneity. Sox9, a transcription factor known for its critical role in embryonic development and tissue homeostasis, has been implicated in various malignancies, including osteosarcoma. This review aims to summarize the current knowledge regarding the role of Sox9 in CSCs in osteosarcoma and its potential implications as a prognosis and therapeutic target.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Sox9: A potential regulator of cancer stem cells in osteosarcoma ; volume:19 ; number:1 ; year:2024 ; extent:9
Open medicine ; 19, Heft 1 (2024) (gesamt 9)
- Creator
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Li, Xiucheng
Lv, Zuo
Zhou, Ping
Zhang, SongOu
Jiang, Chao
- DOI
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10.1515/med-2024-0995
- URN
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urn:nbn:de:101:1-2407081550029.935359536257
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:56 AM CEST
Data provider
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Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Li, Xiucheng
- Lv, Zuo
- Zhou, Ping
- Zhang, SongOu
- Jiang, Chao
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