Atopic dermatitis and chronic kidney disease : : a bidirectional Mendelian randomization study
Abstract: Background: A bidirectional association between atopic dermatitis and chronic kidney disease (CKD) has been revealed in observational studies, whereas the causality of this association was unclear. We conducted a Mendelian randomization study to determine the bidirectional causal association between atopic dermatitis and CKD.
Methods: Independent genetic instruments associated with atopic dermatitis and CKD at the genome-wide significance level were chosen from corresponding meta-analyses of genome-wide association studies. Summary-level data for atopic dermatitis were obtained from the EAGLE Eczema consortium (30,047 cases and 40,835 controls) and FinnGen consortium (7,024 cases and 198,740 controls). Summary-level data for CKD were derived from CKDGen consortium (64,164 cases and 625,219 controls) and FinnGen consortium (3,902 cases and 212,841 controls). The inverse-variance weighted method was used in the main analysis and supplemented with three sensitivity analyses.
Results: Genetic predisposition to atopic dermatitis was associated with an increased risk of CKD. For a one-unit increase in the prevalence of atopic dermatitis, the odds ratio of CKD was 1.07 (95% confidence interval: 1.01–1.12). In the reverse Mendelian randomization analysis, the odds ratio of atopic dermatitis was 1.14 (95% confidence interval: 1.03–1.26) for a one-unit increase in the prevalence of CKD. The associations persisted in sensitivity analyses and no pleiotropy was detected.
Conclusion: This Mendelian randomization study suggests a bidirectional positive association between atopic dermatitis and CKD
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Frontiers in medicine. - 10 (2023) , 1180596, ISSN: 2296-858X
- Ereignis
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Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2023
- Urheber
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Zhang, Han
Yuan, Shuai
Li, Yong
Li, Doudou
Yu, Zengli
Hu, Lidan
Li, Xue
Wang, Yuming
Larsson, Susanna
- DOI
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10.3389/fmed.2023.1180596
- URN
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urn:nbn:de:bsz:25-freidok-2379845
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 14.08.2025, 09:03 UTC
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Zhang, Han
- Yuan, Shuai
- Li, Yong
- Li, Doudou
- Yu, Zengli
- Hu, Lidan
- Li, Xue
- Wang, Yuming
- Larsson, Susanna
- Universität
Entstanden
- 2023
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