Artikel
Examining the causal mediating role of brain pathology on the relationship between diabetes and cognitive impairment: the Cardiovascular Health Study
The paper examines whether diabetes mellitus leads to incident mild cognitive impairment and dementia through brain hypoperfusion and white matter disease. We performed inverse odds ratio weighted causal mediation analyses to decompose the effect of diabetes on cognitive impairment into direct and indirect effects, and we found that approximately a third of the total effect of diabetes is mediated through vascular-related brain pathology. Our findings lend support for a common aetiological hypothesis regarding incident cognitive impairment, which is that diabetes increases the risk of clinical cognitive impairment in part by impacting the vasculature of the brain.
- Sprache
-
Englisch
- Erschienen in
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Journal: Journal of the Royal Statistical Society: Series A (Statistics in Society) ; ISSN: 1467-985X ; Volume: 183 ; Year: 2020 ; Issue: 4 ; Pages: 1705-1726 ; Hoboken, NJ: Wiley
- Thema
-
Alzheimer's disease
Causal inference
Causal mediation analysis
Cognitive neuroscience
Public health
- Ereignis
-
Geistige Schöpfung
- (wer)
-
Andrews, Ryan M.
Shpitser, Ilya
Lopez, Oscar
Longstreth, William T.
Chaves, Paulo H. M.
Kuller, Lewis
Carlson, Michelle C.
- Ereignis
-
Veröffentlichung
- (wer)
-
Wiley
- (wo)
-
Hoboken, NJ
- (wann)
-
2020
- DOI
-
doi:10.1111/rssa.12570
- Handle
- Letzte Aktualisierung
-
10.03.2025, 11:42 MEZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
ZBW - Deutsche Zentralbibliothek für Wirtschaftswissenschaften - Leibniz-Informationszentrum Wirtschaft. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
ZBW - Deutsche Zentralbibliothek für Wirtschaftswissenschaften - Leibniz-Informationszentrum Wirtschaft. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Objekttyp
- Artikel
Beteiligte
- Andrews, Ryan M.
- Shpitser, Ilya
- Lopez, Oscar
- Longstreth, William T.
- Chaves, Paulo H. M.
- Kuller, Lewis
- Carlson, Michelle C.
- Wiley
Entstanden
- 2020
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