Single Atom Engineered Antibiotics Overcome Bacterial Resistance

Abstract: The outbreak of antibiotic‐resistant bacteria, or “superbugs”, poses a global public health hazard due to their resilience against the most effective last‐line antibiotics. Identifying potent antibacterial agents capable of evading bacterial resistance mechanisms represents the ultimate defense strategy. This study shows that –the otherwise essential micronutrient– manganese turns into a broad‐spectrum potent antibiotic when coordinated with a carboxylated nitrogen‐doped graphene. This antibiotic material (termed NGA‐Mn) not only inhibits the growth of a wide spectrum of multidrug‐resistant bacteria but also heals wounds infected by bacteria in vivo and, most importantly, effectively evades bacterial resistance development. NGA‐Mn exhibits up to 25‐fold higher cytocompatibility to human cells than its minimum bacterial inhibitory concentration, demonstrating its potential as a next‐generation antibacterial agent. Experimental findings suggest that NGA‐Mn acts on the outer side of the bacterial cell membrane via a multimolecular collective binding, blocking vital functions in both Gram‐positive and Gram‐negative bacteria. The results underscore the potential of single‐atom engineering toward potent antibiotics, offering simultaneously a long‐sought solution for evading drug resistance development while being cytocompatible to human cells.

Objekt anzeigen

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Single Atom Engineered Antibiotics Overcome Bacterial Resistance ; day:23 ; month:09 ; year:2024 ; extent:12 ; Advanced materials ; (23.09.2024) (gesamt 12)

Beteiligte, Orts- und Zeitangaben

• Urheber: Panáček, David ; Belza, Jan ; Hochvaldová, Lucie ; Baďura, Zdeněk ; Zoppellaro, Giorgio ; Šrejber, Martin ; Malina, Tomáš ; Šedajová, Veronika ; Paloncýová, Markéta ; Langer, Rostislav ; Zdražil, Lukáš ; Zeng, Jianrong ; Li, Lina ; Zhao, En ; Chen, Zupeng ; Xiong, Zhiqiang ; Li, Ruibin ; Panáček, Aleš ; Večeřová, Renata ; Kučová, Pavla ; Kolář, Milan ; Otyepka, Michal ; Bakandritsos, Aristides ; Zbořil, Radek

Weitere Informationen

• DOI: 10.1002/adma.202410652
• URN: urn:nbn:de:101:1-2409231413525.948575450431
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.