Elucidating the chemical and structural composition of breast cancer using Raman micro-spectroscopy

Abstract: The current gold standard for breast cancer (BC) diagnosis is the histopathological assessment of biopsy samples. However, this approach limits the understanding of the disease in terms of biochemical changes. Raman spectroscopy has demonstrated its potential to provide diagnostic information and facilitate the prediction of the biochemical progression for different diseases in a rapid non-destructive manner. Raman micro-spectroscopy was used to characterize and differentiate breast cancer and normal breast samples. In this study, tissue microarrays of breast cancer biopsy samples (n=499) and normal breast (n=79) were analyzed using Raman micro-spectroscopy, and principal component analysis (PCA) was used for feature extraction. Linear discriminant analysis (LDA) was used for feature validation. Normal breast and breast cancer were successfully differentiated with a sensitivity of 90 % and specificity of 78 %. Dominance of lipids, specifically fatty acids, was identified in the nor.... https://www.excli.de/index.php/excli/article/view/3962

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Elucidating the chemical and structural composition of breast cancer using Raman micro-spectroscopy ; volume:20 ; day:02 ; month:07 ; year:2021 ; EXCLI journal ; 20 (02.07.2021)

Contributors, Places and Time

• Creator: Lazaro-Pacheco, Daniela ; Shaaban, Abeer M. ; Titiloye, Nicholas Akinwale ; Rehman, Shazza ; Rehman, Ihtesham

Further information

• DOI: 10.17179/excli2021-3962
• URN: urn:nbn:de:101:1-2021090114331129872877
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:38 AM CEST