Changes in Internal Cerebral Vein Pulsation and Intraventricular Hemorrhage in Extremely Preterm Infants

Objectives: To investigate the relationship between internal cerebral vein (ICV) pulsation and intraventricular hemorrhage (IVH) and to identify the cutoff values that predict IVH. We hypothesized that the severity of ICV flow pulsations was related to IVH severity. Study Design: In this prospective observational study, ICV flow was measured in 61 extremely preterm infants using ultrasonography every 12 h until 96 h after birth and on days 7, 14, and 28. The ICV pulsation index (ICVPI = minimum/maximum ICV speed) was calculated and compared among the groups determined by Papile IVH classification. The ICVPI cutoff values for IVH were determined by receiver operating characteristic curve analysis. Results: Compared with those in the no IVH group (n=51), the ICVPI median values in the severe IVH (Grade 3–4) group (n=5) were lower at 25–96 h and on day 7, whereas those in the mild IVH (Grade 1–2) group (n=5) were lower at 37–60 h. All severe IVH events were initially detected within 60 h after birth. The ICVPI cutoff values for severe IVH were 0.92 at 13–24 h, 0.42 at 25–36 h, 0.58 at 37–48 h, and 0.55 at 49–60 h. Infants whose ICVPI values were below the cutoff value ≥3 times between 13 and 60 h had a significantly higher severe IVH incidence than those whose ICVPI values were below the cutoff value ≤2 times (57.1% vs. 1.9%, p<0.001). Conclusion: Our results indicate that severe IVH had sustained pronounced internal cerebral vein pulsations and that the ICVPI values may help predict severe IVH. Further research on strategies to decrease venous pressure for IVH prevention is needed.

Alternative title
Cerebral Vein Pulsation and Premature Intraventricular Hemorrhage
Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Changes in Internal Cerebral Vein Pulsation and Intraventricular Hemorrhage in Extremely Preterm Infants ; day:05 ; month:04 ; year:2022
American journal of perinatology ; (05.04.2022)

Contributor
Tanaka, Kenichi
Matsumoto, Shirou
MInamitani, Youhei
Imamura, Hiroko
Yoshimatsu, Hidetaka
Nakamura, Tomomi
Naramura, Tetsuo
Iwai, Masanori
Mitsubuchi, Hiroshi
Nakamura, Kimitoshi

DOI
10.1055/a-1817-6638
URN
urn:nbn:de:101:1-2022051911021437470253
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
15.08.2025, 7:34 AM CEST

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Associated

  • Tanaka, Kenichi
  • Matsumoto, Shirou
  • MInamitani, Youhei
  • Imamura, Hiroko
  • Yoshimatsu, Hidetaka
  • Nakamura, Tomomi
  • Naramura, Tetsuo
  • Iwai, Masanori
  • Mitsubuchi, Hiroshi
  • Nakamura, Kimitoshi

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