Chemical Cocktail Induces Hematopoietic Reprogramming and Expands Hematopoietic Stem/Progenitor Cells
Abstract: Generation of hematopoietic stem/progenitor cells (HSPCs) via cell expansion or cell reprogramming has been widely achieved by overexpression of transcription factors. Herein, it is reported that without introducing exogenous genes, mouse fibroblasts can be reprogrammed into hemogenic cells based on lineage tracing analysis, which further develop into hematopoietic cells, by treatment of cocktails of chemical compounds. The chemical cocktails also reprogram differentiated hematopoietic cells back into HSPC‐like cells. Most importantly, the chemical cocktails enabling hematopoietic reprogramming robustly promote HSPC proliferation ex vivo. The expanded HSPCs acquire enhanced capacity of hematopoietic reconstruction in vivo. Single‐cell sequencing analysis verifies the expansion of HSPCs and the cell reprogramming toward potential generation of HSPCs at the same time by the chemical cocktail treatment. Thus, the proof‐of‐concept findings not only demonstrate that hematopoietic reprogramming can be achieved by chemical compounds but also provide a promising strategy for acquisition of HSPCs by chemical cocktail‐enabled double effects.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Chemical Cocktail Induces Hematopoietic Reprogramming and Expands Hematopoietic Stem/Progenitor Cells ; volume:7 ; number:1 ; year:2020 ; extent:12
Advanced science ; 7, Heft 1 (2020) (gesamt 12)
- Urheber
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Zhou, Yi
Zhu, Xingli
Dai, Yuting
Xiong, Shumin
Wei, Chuijin
Yu, Pei
Tang, Yuewen
Wu, Liang
Li, Jianfeng
Liu, Dan
Wang, Yanlin
Chen, Zhu
Chen, Sai‐Juan
Huang, Jinyan
Cheng, Lin
- DOI
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10.1002/advs.201901785
- URN
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urn:nbn:de:101:1-2022062411305238410622
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.02.2025, 03:36 MEZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Zhou, Yi
- Zhu, Xingli
- Dai, Yuting
- Xiong, Shumin
- Wei, Chuijin
- Yu, Pei
- Tang, Yuewen
- Wu, Liang
- Li, Jianfeng
- Liu, Dan
- Wang, Yanlin
- Chen, Zhu
- Chen, Sai‐Juan
- Huang, Jinyan
- Cheng, Lin
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