Non‐apoptotic caspase activation ensures the homeostasis of ovarian somatic stem cells
Abstract: Current evidence has associated caspase activation with the regulation of basic cellular functions without causing apoptosis. Malfunction of non‐apoptotic caspase activities may contribute to specific neurological disorders, metabolic diseases, autoimmune conditions and cancers. However, our understanding of non‐apoptotic caspase functions remains limited. Here, we show that non‐apoptotic caspase activation prevents the intracellular accumulation of the Patched receptor in autophagosomes and the subsequent Patched‐dependent induction of autophagy in Drosophila follicular stem cells. These events ultimately sustain Hedgehog signalling and the physiological properties of ovarian somatic stem cells and their progeny under moderate thermal stress. Importantly, our key findings are partially conserved in ovarian somatic cells of human origin. These observations attribute to caspases a pro‐survival role under certain cellular conditions.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Non‐apoptotic caspase activation ensures the homeostasis of ovarian somatic stem cells ; day:11 ; month:04 ; year:2023 ; extent:18
EMBO reports / European Molecular Biology Organization ; (11.04.2023) (gesamt 18)
- Urheber
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Galasso, Alessia
Xu, Derek Cui
Hill, Claire
Iakovleva, Daria
Stefana, Maria Irina
Baena‐Lopez, Luis Alberto
- DOI
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10.15252/embr.202051716
- URN
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urn:nbn:de:101:1-2023041115075509297090
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:49 MESZ
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Beteiligte
- Galasso, Alessia
- Xu, Derek Cui
- Hill, Claire
- Iakovleva, Daria
- Stefana, Maria Irina
- Baena‐Lopez, Luis Alberto
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