Discordant clinical outcomes of congenital Zika virus infection in twin pregnancies

Abstract: Congenital Zika syndrome is an emergent cause of a congenital infectious disorder, resulting in severe damage to the central nervous system and microcephaly. Despite advances in understanding the pathophysiology of the disease, we still do not know all the mechanisms enrolled in the vertical transmission of the virus. As has already been reported in other types of congenital infectious disorders in dizygotic twin pregnancies, it is possible that the virus affects only one of the fetuses. In this article, we report on two cases of twin pregnancies exposed to the Zika virus, but with only one of the fetuses affected with microcephaly and brain damage. This indicates the urgent need for more studies regarding the pathophysiology of viral infection and the mechanisms involved in the natural protection against the virus.

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• Alternative title: Evolução clínica discordante da infecção congénita do vírus Zika em gestação gemelar
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Discordant clinical outcomes of congenital Zika virus infection in twin pregnancies ; volume:75 ; number:06 ; year:2017 ; pages:381-386 ; Arquivos de neuro-psiquiatria ; 75, Heft 06 (2017), 381-386

Contributors, Places and Time

• Contributor: Linden, Vanessa van der ; Linden, Hélio van der ; Leal, Mariana de Carvalho ; Rolim, Epitacio Leite ; Linden, Ana van der ; Aragão, Maria de Fátima Viana Vasco ; Brainer-Lima, Alessandra Mertens ; Cruz, Danielle Di Cavalcanti Sousa ; Ventura, Liana O. ; Florêncio, Telma Lúcia Tabosa ; Cordeiro, Marli Tenório ; Caudas, Silvio da Silva ; Ramos, Regina Coeli

Further information

• DOI: 10.1590/0004-282X20170066
• URN: urn:nbn:de:101:1-2023101911280682211238
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.