Expression of connexins and pannexins in diseased human liver

Abstract: Connexin proteins can form hexameric hemichannels and gap junctions that mediate paracrine and direct intercellular communication, respectively. Gap junction activity is crucial for the maintenance of hepatic homeostasis, while connexin hemichannels become particularly active in liver disease, such as hepatitis, fibrosis, cholestasis or even hepatocellular carcinoma. Channels consisting of connexin-like proteins named pannexins have been directly linked to liver inflammation and cell death. The goal of the present study was to characterize the expression and subcellular localization of connexins and pannexins in liver of patients suffering from various chronic and neoplastic liver diseases. Specifically, real-time quantitative reverse transcription polymerase chain reaction, immunoblotting and immunohistochemistry analyses were performed on human liver biopsies. It was found that pannexin1 and pannexin2 gene expression are correlated to a certain degree, as is pannexin1 protein exp.... https://www.excli.de/index.php/excli/article/view/5163

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• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Expression of connexins and pannexins in diseased human liver ; volume:21 ; year:2022 ; EXCLI journal ; 21 (2022)

Contributors, Places and Time

• Creator: Leroy, Kaat ; Vilas-Boas, Vânia ; Gijbels, Eva ; Vanderborght, Bart ; Devisscher, Lindsey ; Cogliati, Bruno ; Van Den Bossche, Bert ; Colle, Isabelle ; Vinken, Mathieu

Further information

• DOI: 10.17179/excli2022-5163
• URN: urn:nbn:de:101:1-2022091603130698573228
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.