The relevance of adhesion G protein-coupled receptors in metabolic functions
Abstract: G protein-coupled receptors (GPCRs) modulate a variety of physiological functions and have been proven to be outstanding drug targets. However, approximately one-third of all non-olfactory GPCRs are still orphans in respect to their signal transduction and physiological functions. Receptors of the class of Adhesion GPCRs (aGPCRs) are among these orphan receptors. They are characterized by unique features in their structure and tissue-specific expression, which yields them interesting candidates for deorphanization and testing as potential therapeutic targets. Capable of G-protein coupling and non-G protein-mediated function, aGPCRs may extend our repertoire of influencing physiological function. Besides their described significance in the immune and central nervous systems, growing evidence indicates a high importance of these receptors in metabolic tissue. RNAseq analyses revealed high expression of several aGPCRs in pancreatic islets, adipose tissue, liver, and intestine but also in neurons governing food intake. In this review, we focus on aGPCRs and their function in regulating metabolic pathways. Based on current knowledge, this receptor class represents high potential for future pharmacological approaches addressing obesity and other metabolic diseases.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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The relevance of adhesion G protein-coupled receptors in metabolic functions ; volume:403 ; number:2 ; year:2022 ; pages:195-209 ; extent:015
Biological chemistry ; 403, Heft 2 (2022), 195-209 (gesamt 015)
- Creator
- DOI
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10.1515/hsz-2021-0146
- URN
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urn:nbn:de:101:1-2408061644559.791789679243
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.09.2026, 2:53 PM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Kaczmarek, Isabell
- Suchý, Tomáš
- Prömel, Simone
- Schöneberg, Torsten
- Liebscher, Ines
- Thor, Doreen
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Expression profile of the entire family of AdhesionG protein-coupled receptors in mouse and rat
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