Osteogenic‐Like Microenvironment of Renal Interstitium Induced by Osteomodulin Contributes to Randall's Plaque Formation
Abstract: Calcium oxalate (CaOx) kidney stones are common and recurrent, lacking pharmacological prevention. Randall's plaques (RPs), calcium deposits in renal papillae, serve as niduses for some CaOx stones. This study explores the role of osteogenic‐like cells in RP formation resembling ossification. CaP crystals deposit around renal tubules, interstitium, and blood vessels in RP tissues. Human renal interstitial fibroblasts (hRIFs) exhibit the highest osteogenic‐like differentiation potential compared to chloride voltage‐gated channel Ka positive tubular epithelial cells, aquaporin 2 positive collecting duct cells, and vascular endothelial cells, echoing the upregulated osteogenic markers primarily in hRIFs within RP tissues. Utilizing RNA‐seq, osteomodulin (OMD) is found to be upregulated in hRIFs within RP tissues and hRIFs following osteogenic induction. Furthermore, OMD colocalizes with CaP crystals and calcium vesicles within RP tissues. OMD can enhance osteogenic‐like differentiation of hRIFs in vitro and in vivo. Additionally, crystal deposits are attenuated in mice with Omd deletion in renal interstitial fibroblasts following CaOx nephrocalcinosis induction. Mechanically, a positive feedback loop of OMD/BMP2/BMPR1A/RUNX2/OMD drives hRIFs to adopt osteogenic‐like fates, by which OMD induces osteogenic‐like microenvironment of renal interstitium to participate in RP formation. We identify OMD upregulation as a pathological feature of RP, paving the way for preventing CaOx stones.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Osteogenic‐Like Microenvironment of Renal Interstitium Induced by Osteomodulin Contributes to Randall's Plaque Formation ; day:03 ; month:09 ; year:2024 ; extent:19
Advanced science ; (03.09.2024) (gesamt 19)
- Creator
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Zhu, Zewu
Huang, Fang
Gao, Meng
Liu, Minghui
Zhang, Youjie
Tang, Liang
Wu, Jian
Yu, Hao
He, Cheng
Chen, Jinbo
Yang, Zhongqing
Chen, Zhiyong
Li, Yang
Chen, Hequn
Lei, Ting
Zeng, Feng
Cui, Yu
- DOI
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10.1002/advs.202405875
- URN
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urn:nbn:de:101:1-2409041421429.377004417071
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
- 15.08.2025, 7:27 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Zhu, Zewu
- Huang, Fang
- Gao, Meng
- Liu, Minghui
- Zhang, Youjie
- Tang, Liang
- Wu, Jian
- Yu, Hao
- He, Cheng
- Chen, Jinbo
- Yang, Zhongqing
- Chen, Zhiyong
- Li, Yang
- Chen, Hequn
- Lei, Ting
- Zeng, Feng
- Cui, Yu
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