Chitosan nanoparticles based nanovaccines for cancer immunotherapy
Abstract: Cancer immunotherapy based on tumor vaccine is very promising and intriguing for carcinoma treatment. Herein, antitumor nanovaccines consisting of self-assembled chitosan (CS) nanoparticles and two-component mucin1 (MUC1) glycopeptide antigens were reported. Two different kinds of polyanionic electrolyte [sodium tripolyphosphate (TPP) and γ-poly-L-glutamic acid (γ-PGA)] were combined with chitosan polymers to fabricate the diameter of nearly 400–500 nm CS nanoparticles by electrostatic interactions. The nanovaccines were constructed by physically mixing MUC1 glycopeptide antigens with CS nanoparticles, which reduced vaccine constructing complexity compared with traditional chemical total synthetic vaccines. Immunological studies revealed that the CS/γ-PGA nanoparticle could dramatically enhance the immunogenicity of peptide epitope and produce significantly high titers of IgG antibody which was even better than Freund’s adjuvant-containing vaccines.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Chitosan nanoparticles based nanovaccines for cancer immunotherapy ; volume:89 ; number:7 ; year:2017 ; pages:931-939 ; extent:9
Pure and applied chemistry ; 89, Heft 7 (2017), 931-939 (gesamt 9)
- Urheber
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Chen, Pu-Guang
Huang, Zhi-Hua
Sun, Zhan-Yi
Gao, Yue
Liu, Yan-Fang
Shi, Lei
Chen, Yong-Xiang
Zhao, Yu-Fen
Li, Yan-Mei
- DOI
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10.1515/pac-2016-0913
- URN
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urn:nbn:de:101:1-2024030613215485855678
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:51 MESZ
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Beteiligte
- Chen, Pu-Guang
- Huang, Zhi-Hua
- Sun, Zhan-Yi
- Gao, Yue
- Liu, Yan-Fang
- Shi, Lei
- Chen, Yong-Xiang
- Zhao, Yu-Fen
- Li, Yan-Mei
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