Biomarkers of vascular injury and type 2 diabetes : : a prospective study, systematic review and meta-analysis

Abstract: Data on biomarkers of vascular injury and type 2 diabetes (T2D) risk from prospective studies are lacking. We evaluated seven biomarkers of vascular injury in relation to T2D. Additionally, a meta-analysis was performed. From the EPIC–Heidelberg cohort, 2224 participants were followed-up from baseline for 16 (median) years. E-Selectin, P-Selectin, intercellular adhesion molecule 3 (ICAM3), thrombomodulin, thrombopoietin, glycoprotein IIb/IIIa and fibrinogen levels were measured in baseline blood samples. The systematic review and meta-analysis included prospective studies identified through MEDLINE and Web of Science that investigated the association between mentioned biomarkers and T2D. The study population included 55% women, median age was 50 years, and 163 developed T2D. ICAM3 was associated with lower T2D risk (fully adjusted HRhighest vs. lowest tertile 0.62 (95% CI: 0.43, 0.91)), but no other studies on ICAM3 were identified. Overall, fifteen studies were included in the systematic review and meta-analysis (6,171 cases). E-Selectin was associated with higher T2D risk HRper SD: 1.34 (95% CI: 1.16, 1.54; I2 = 63%, n = 9 studies), while thrombomodulin was associated with lower risk HRper SD: 0.82 (95% CI: 0.71, 0.95; I2 = 0%, n = 2 studies). In the EPIC–Heidelberg, ICAM3 was associated with lower T2D risk. The meta-analysis showed a consistent positive association between E-Selectin and T2D. It was also suggestive of an inverse association between thrombomodulin and T2D, although further studies are needed to corroborate this finding

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Journal of clinical medicine. - 8, 12 (2019) , 2075, ISSN: 2077-0383

Classification and Topics

• Keyword: Epidemiologie ; Diabetes mellitus Typ 2 ; E-Selectin ; Thrombomodulin

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2020
• Creator: Pletsch-Borba, Laura ; Watzinger, Cora ; Turzanski Fortner, Renée ; Katzke, Verena ; Schwingshackl, Lukas ; Sowah, Solomon A. ; Hüsing, Anika ; Johnson, Theron S. ; Groß-Weissmann, Marie-Luise ; González Maldonado, Sandra ; Hoffmeister, Michael ; Bugert, Peter ; Kaaks, Rudolf ; Grafetstätter, Mirja ; Kühn, Tilman

Further information

• DOI: 10.3390/jcm8122075
• URN: urn:nbn:de:bsz:25-freidok-1545518
• Rights: Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 25.03.2025, 1:57 PM CET