Grade I meningiomas with atypical characteristics: a worse prognosis

Abstract: The study reviewed the histology of cases of grade I meningiomas with spontaneous necrosis, grade I without necrosis and grade II meningiomas, to evaluate the histological and immunohistochemical factors of the patients prognosis, while correlating the clinicopathological features with the clinical follow-up of the patients. A review of 47 cases from the Department of Pathology of UNIFESP was performed and the samples were submitted to immunohistochemical examination with the p53 protein, Ki-67 cell proliferation factor and progesterone receptor markers. A greater expression was found in the progression of several degrees of aggressiveness for p53 and Ki-67, and a higher frequency of progesterone receptors in the lower degrees. The group of grade I meningiomas with spontaneous necrosis showed histological and immunohistochemical indexes that approximate those of the grade II meningioma. This suggests a worse prognosis for grade I meningiomas with necrosis.

Object Details

• Alternative title: Meningiomas grau I com caractersticas atpicas: um pior prognstico
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Grade I meningiomas with atypical characteristics: a worse prognosis ; volume:76 ; number:11 ; year:2018 ; pages:756-759 ; Arquivos de neuro-psiquiatria ; 76, Heft 11 (2018), 756-759

Contributors, Places and Time

• Contributor: Marcos, Dbora S. ; Paiva, Manoel A. ; Ges, Pedro ; Oshima, Celina T. F. ; Silva, Marcelo S. ; Stvale, Joo N.

Further information

• DOI: 10.1590/0004-282X20180121
• URN: urn:nbn:de:101:1-2023100513010279280661
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:48 AM CEST