Pre-medication with oral anticoagulants is associated with better outcomes in a large multinational COVID-19 cohort with cardiovascular comorbidities

Abstract: Aims

Coagulopathy and venous thromboembolism are common findings in coronavirus disease 2019 (COVID-19) and are associated with poor outcome. Timely initiation of anticoagulation after hospital admission was shown to be beneficial. In this study we aim to examine the association of pre-existing oral anticoagulation (OAC) with outcome among a cohort of SARS-CoV-2 infected patients.
Methods and results

We analysed the data from the large multi-national Lean European Open Survey on SARS-CoV-2 infected patients (LEOSS) from March to August 2020. Patients with SARS-CoV-2 infection were eligible for inclusion. We retrospectively analysed the association of pre-existing OAC with all-cause mortality. Secondary outcome measures included COVID-19-related mortality, recovery and composite endpoints combining death and/or thrombotic event and death and/or bleeding event. We restricted bleeding events to intracerebral bleeding in this analysis to ensure clinical relevance and to limit reporting errors. A total of 1 433 SARS-CoV-2 infected patients were analysed, while 334 patients (23.3%) had an existing premedication with OAC and 1 099 patients (79.7%) had no OAC. After risk adjustment for comorbidities, pre-existing OAC showed a protective influence on the endpoint death (OR 0.62, P = 0.013) as well as the secondary endpoints COVID-19-related death (OR 0.64, P = 0.023) and non-recovery (OR 0.66, P = 0.014). The combined endpoint death or thrombotic event tended to be less frequent in patients on OAC (OR 0.71, P = 0.056).
Conclusions

Pre-existing OAC is protective in COVID-19, irrespective of anticoagulation regime during hospital stay and independent of the stage and course of disease

Objekt anzeigen

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: Clinical research in cardiology. - 111 (2022) , 322–332, ISSN: 1861-0692

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2021
• Urheber: Rieder, Marina ; Gauchel, Nadine ; Kaier, Klaus ; Jakob, Carolin E. M. ; Borgmann, Stefan ; Claßen, Annika ; Schneider, Jochen ; Eberwein, Lukas ; Lablans, Martin ; Rüthrich, Maria Madeleine ; Dolff, Sebastian Conrad Johannes ; Wille, Kai ; Haselberger, Martina Maria ; Heuzeroth, Hanno ; Bode, Christoph ; Zur Mühlen, Constantin von ; Rieg, Siegbert ; Dürschmied, Daniel

Weitere Informationen

• DOI: 10.1007/s00392-021-01939-3
• URN: urn:nbn:de:bsz:25-freidok-2215106
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.