Is styrene competitive for dopamine receptor binding?
Abstract: The potential role of styrene oxide in altering the dopaminergic pathway in the ear is investigated by means of molecular docking and molecular dynamics simulations. We estimate the binding affinity of both styrene oxide and dopamine to the dopaminergic receptor DrD2 by computing the free-energy difference, ∆G, between the configuration where the ligand is bound to the receptor and the situation in which it is “infinitely” far away from it. The results show that the styrene oxide has a somewhat lower affinity for binding with respect to dopamine, which, however, may not be enough to prevent exogenous high concentration styrene oxide to compete with endogenous dopamine for DrD2 binding.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Is styrene competitive for dopamine receptor binding? ; volume:13 ; number:1 ; year:2022 ; pages:200-206 ; extent:7
Biomolecular concepts ; 13, Heft 1 (2022), 200-206 (gesamt 7)
- Urheber
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De Santis, Emiliano
Minicozzi, Velia
Rossi, Giancarlo
Stellato, Francesco
Morante, Silvia
- DOI
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10.1515/bmc-2022-0016
- URN
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urn:nbn:de:101:1-2022090214124532304967
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:34 MESZ
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Beteiligte
- De Santis, Emiliano
- Minicozzi, Velia
- Rossi, Giancarlo
- Stellato, Francesco
- Morante, Silvia
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