Nicotine-induced memory impairment by increasing brain oxidative stress
Abstract: Male Wistar rats were subjected to chronic nicotine treatment (0.3 mg/kg; 7 continuous days) and their memory performance was studied by means of Y-maze and multi-trial passive avoidance tasks. Nicotine significantly decreased spontaneous alternation in Y-maze task and step-through-latency in the multi-trial passive avoidance task, suggesting effects on both short-term memory and long-term memory, respectively. In addition, nicotine induced neuronal apoptosis, DNA fragmentation, reduced antioxidant enzymes activity, and increased production of lipid peroxidation and reactive oxygen species, suggesting pro-oxidant activity. Our results provide further support that nicotine-induced memory impairment is due to an increase in brain oxidative stress in rats.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Nicotine-induced memory impairment by increasing brain oxidative stress ; volume:4 ; number:3 ; year:2009 ; pages:335-342 ; extent:8
Open life sciences ; 4, Heft 3 (2009), 335-342 (gesamt 8)
- Creator
-
Hritcu, Lucian
Ciobica, Alin
Gorgan, Lucian
- DOI
-
10.2478/s11535-009-0029-x
- URN
-
urn:nbn:de:101:1-2409201848056.309137324649
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:33 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Hritcu, Lucian
- Ciobica, Alin
- Gorgan, Lucian
Other Objects (12)
Amelioration of the haloperidol-induced memory impairment and brain oxidative stress by cinnarizine
Nicotine psychopharmacology
Post-stroke memory impairment among patients with vascular mild cognitive impairment
Oral administration of coenzyme Q10 ameliorates memory impairment induced by nicotine-ethanol abstinence through restoration of biochemical changes in male rat hippocampal tissues
Smoking and nicotine dependence in context of exposure therapy for panic disorder and Agoraphobia : patients` impairment, Therapy-Outcome and change in nicotine consumption
Emilia coccinae (SIMS) G Extract improves memory impairment, cholinergic dysfunction, and oxidative stress damage in scopolamine-treated rats
Nicotine and Arteriosclerosis
Effects of right-unilateral 6-hydroxydopamine infusion-induced memory impairment and oxidative stress: relevance for Parkinson’s disease
The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats
Imperfect memory and the preference for increasing payments
Nicotine dependence and role of pharmacist in nicotine addiction control
Small pouches, but high nicotine doses—nicotine delivery and acute effects after use of tobacco-free nicotine pouches
Amelioration of the haloperidol-induced memory impairment and brain oxidative stress by cinnarizine
Nicotine psychopharmacology
Post-stroke memory impairment among patients with vascular mild cognitive impairment
Oral administration of coenzyme Q10 ameliorates memory impairment induced by nicotine-ethanol abstinence through restoration of biochemical changes in male rat hippocampal tissues
Smoking and nicotine dependence in context of exposure therapy for panic disorder and Agoraphobia : patients` impairment, Therapy-Outcome and change in nicotine consumption
Emilia coccinae (SIMS) G Extract improves memory impairment, cholinergic dysfunction, and oxidative stress damage in scopolamine-treated rats
Nicotine and Arteriosclerosis
Effects of right-unilateral 6-hydroxydopamine infusion-induced memory impairment and oxidative stress: relevance for Parkinson’s disease
The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats
Imperfect memory and the preference for increasing payments
Nicotine dependence and role of pharmacist in nicotine addiction control
Small pouches, but high nicotine doses—nicotine delivery and acute effects after use of tobacco-free nicotine pouches
Amelioration of the haloperidol-induced memory impairment and brain oxidative stress by cinnarizine
Nicotine psychopharmacology
Post-stroke memory impairment among patients with vascular mild cognitive impairment
Oral administration of coenzyme Q10 ameliorates memory impairment induced by nicotine-ethanol abstinence through restoration of biochemical changes in male rat hippocampal tissues
Smoking and nicotine dependence in context of exposure therapy for panic disorder and Agoraphobia : patients` impairment, Therapy-Outcome and change in nicotine consumption
Emilia coccinae (SIMS) G Extract improves memory impairment, cholinergic dysfunction, and oxidative stress damage in scopolamine-treated rats
Nicotine and Arteriosclerosis
Effects of right-unilateral 6-hydroxydopamine infusion-induced memory impairment and oxidative stress: relevance for Parkinson’s disease
The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats
Imperfect memory and the preference for increasing payments
Nicotine dependence and role of pharmacist in nicotine addiction control