Calming the Nerves via the Immune Instructive Physiochemical Properties of Self‐Assembling Peptide Hydrogels
Abstract: Current therapies for the devastating damage caused by traumatic brain injuries (TBI) are limited. This is in part due to poor drug efficacy to modulate neuroinflammation, angiogenesis and/or promoting neuroprotection and is the combined result of challenges in getting drugs across the blood brain barrier, in a targeted approach. The negative impact of the injured extracellular matrix (ECM) has been identified as a factor in restricting post‐injury plasticity of residual neurons and is shown to reduce the functional integration of grafted cells. Therefore, new strategies are needed to manipulate the extracellular environment at the subacute phase to enhance brain regeneration. In this review, potential strategies are to be discussed for the treatment of TBI by using self‐assembling peptide (SAP) hydrogels, fabricated via the rational design of supramolecular peptide scaffolds, as an artificial ECM which under the appropriate conditions yields a supramolecular hydrogel. Sequence selection of the peptides allows the tuning of these hydrogels' physical and biochemical properties such as charge, hydrophobicity, cell adhesiveness, stiffness, factor presentation, degradation profile and responsiveness to (external) stimuli. This review aims to facilitate the development of more intelligent biomaterials in the future to satisfy the parameters, requirements, and opportunities for the effective treatment of TBI.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Calming the Nerves via the Immune Instructive Physiochemical Properties of Self‐Assembling Peptide Hydrogels ; day:29 ; month:11 ; year:2023 ; extent:23
Advanced science ; (29.11.2023) (gesamt 23)
- Creator
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Mahmoudi, Negar
Mohamed, Elmira
Dehnavi, Shiva Soltani
Aguilar, Lilith M. Caballero
Harvey, Alan R.
Parish, Clare L.
Williams, Richard J.
Nisbet, David R.
- DOI
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10.1002/advs.202303707
- URN
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urn:nbn:de:101:1-2023113014332713828086
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
- 15.08.2025, 7:24 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Mahmoudi, Negar
- Mohamed, Elmira
- Dehnavi, Shiva Soltani
- Aguilar, Lilith M. Caballero
- Harvey, Alan R.
- Parish, Clare L.
- Williams, Richard J.
- Nisbet, David R.
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