A Synthetic Minimal Beating Axoneme

Abstract: Cilia and flagella are beating rod‐like organelles that enable the directional movement of microorganisms in fluids and fluid transport along the surface of biological organisms or inside organs. The molecular motor axonemal dynein drives their beating by interacting with microtubules. Constructing synthetic beating systems with axonemal dynein capable of mimicking ciliary beating still represents a major challenge. Here, the bottom‐up engineering of a sustained beating synthoneme consisting of a pair of microtubules connected by a series of periodic arrays of approximately eight axonemal dyneins is reported. A model leads to the understanding of the motion through the cooperative, cyclic association–dissociation of the molecular motor from the microtubules. The synthoneme represents a bottom‐up self‐organized bio‐molecular machine at the nanoscale with cilia‐like properties.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: A Synthetic Minimal Beating Axoneme ; day:11 ; month:07 ; year:2022 ; extent:12 ; Small ; (11.07.2022) (gesamt 12)

Contributors, Places and Time

• Creator: Guido, Isabella ; Vilfan, Andrej ; Ishibashi, Kenta ; Sakakibara, Hitoshi ; Shiraga, Misaki ; Bodenschatz, Eberhard ; Golestanian, Ramin ; Oiwa, Kazuhiro

Further information

• DOI: 10.1002/smll.202107854
• URN: urn:nbn:de:101:1-2022071115231291530553
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:36 AM CEST