Influence of nutritional status and physical exercise on immune response in metabolic syndrome
Abstract: Metabolic Syndrome (MetS) is a cluster of metabolic alterations mostly related to visceral adiposity, which in turn promotes glucose intolerance and a chronic systemic inflammatory state, characterized by immune cell infiltration. Such immune system activation increases the risk of severe disease subsequent to viral infections. Strong correlations between elevated body mass index (BMI), type-2-diabetes and increased risk of hospitalization after pandemic influenza H1N1 infection have been described. Similarly, a correlation between elevated blood glucose level and SARS-CoV-2 infection severity and mortality has been described, indicating MetS as an important predictor of clinical outcomes in patients with COVID-19. Adipose secretome, including two of the most abundant and well-studied adipokines, leptin and interleukin-6, is involved in the regulation of energy metabolism and obesity-related low-grade inflammation. Similarly, skeletal muscle hormones—called myokines—released in response to physical exercise affect both metabolic homeostasis and immune system function. Of note, several circulating hormones originate from both adipose tissue and skeletal muscle and display different functions, depending on the metabolic context. This review aims to summarize recent data in the field of exercise immunology, investigating the acute and chronic effects of exercise on myokines release and immune system function
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Nutrients. - 14, 10 (2022) , 2054, ISSN: 2072-6643
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2022
- Creator
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Lombardo, Mauro
Feraco, Alessandra
Bellia, Chiara
Prisco, Luigi
D’Ippolito, Ilenia
Padua, Elvira
Storz, Maximilian
Lauro, Davide
Caprio, Massimiliano
Bellia, Alfonso
- DOI
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10.3390/nu14102054
- URN
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urn:nbn:de:bsz:25-freidok-2271019
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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25.03.2025, 1:44 PM CET
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Lombardo, Mauro
- Feraco, Alessandra
- Bellia, Chiara
- Prisco, Luigi
- D’Ippolito, Ilenia
- Padua, Elvira
- Storz, Maximilian
- Lauro, Davide
- Caprio, Massimiliano
- Bellia, Alfonso
- Universität
Time of origin
- 2022
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Acquired immune deficiency syndrome, [1]
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Vitam D 3 and metabolic syndrome
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Acquired immune deficiency syndrome : AIDS
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