Rescaling NMR for a Larger Deployment in Drug Discovery: Hyperpolarization and Benchtop NMR as Potential Game‐Changers
Abstract: Nuclear magnetic resonance (NMR) is recognized as the gold standard method in fragment‐based drug design for screening, hit validation, and affinity determination. However, its deployment at a large scale is limited by the cost and expertise needed to implement NMR as a routine drug discovery method. The increase in the adoption of fragment‐based drug design created a need for biophysics to provide high‐quality data for weak ligand‐target interactions that can be implemented at scale. NMR must adapt its position in drug design operations to enter this new era. The recent development of commercially available benchtop NMR spectrometers in combination with hyperpolarization methods represents an opportunity for highly deployable and scalable systems.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Rescaling NMR for a Larger Deployment in Drug Discovery: Hyperpolarization and Benchtop NMR as Potential Game‐Changers ; day:05 ; month:09 ; year:2024 ; extent:15
Chemistry methods ; (05.09.2024) (gesamt 15)
- Urheber
-
Bütikofer, Matthias
Stadler, Gabriela R.
Torres, Felix
- DOI
-
10.1002/cmtd.202400009
- URN
-
urn:nbn:de:101:1-2409061407268.408284492386
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 14.08.2022, 00:20 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Bütikofer, Matthias
- Stadler, Gabriela R.
- Torres, Felix
Ähnliche Objekte (12)
Hyperpolarization methods in NMR spectroscopy
Hyperpolarization with parahydrogen in NMR
Hyperpolarization-enhanced NMR spectroscopy of unaltered biofluids using photo-CIDNP
Photo-CIDNP MAS NMR : generation, transfer and application of nuclear hyperpolarization
Pulsed control methods with applications to nuclear hyperpolarization and nanoscale NMR
13 C and 15 N Benchtop NMR Detection of Metabolites via Relayed Hyperpolarization **
NMR sensitivity enhancement of functional biomolecules : design and development of PHIP-based hyperpolarization approaches
Parahydrogen Hyperpolarization Allows Direct NMR Detection of α‐Amino Acids in Complex (Bio)mixtures
Parahydrogen Hyperpolarization Allows Direct NMR Detection of α‐Amino Acids in Complex (Bio)mixtures
NMR in target driven drug discovery: why not?
Fragment Screening and Fast Micromolar Detection on a Benchtop NMR Spectrometer Boosted by Photoinduced Hyperpolarization
Deuteron‐Decoupled Singlet NMR in Low Magnetic Fields: Application to the Hyperpolarization of Succinic Acid **
Hyperpolarization methods in NMR spectroscopy
Hyperpolarization with parahydrogen in NMR
Hyperpolarization-enhanced NMR spectroscopy of unaltered biofluids using photo-CIDNP
Photo-CIDNP MAS NMR : generation, transfer and application of nuclear hyperpolarization
Pulsed control methods with applications to nuclear hyperpolarization and nanoscale NMR
13 C and 15 N Benchtop NMR Detection of Metabolites via Relayed Hyperpolarization **
NMR sensitivity enhancement of functional biomolecules : design and development of PHIP-based hyperpolarization approaches
Parahydrogen Hyperpolarization Allows Direct NMR Detection of α‐Amino Acids in Complex (Bio)mixtures
Parahydrogen Hyperpolarization Allows Direct NMR Detection of α‐Amino Acids in Complex (Bio)mixtures
NMR in target driven drug discovery: why not?
Fragment Screening and Fast Micromolar Detection on a Benchtop NMR Spectrometer Boosted by Photoinduced Hyperpolarization
Deuteron‐Decoupled Singlet NMR in Low Magnetic Fields: Application to the Hyperpolarization of Succinic Acid **
Hyperpolarization methods in NMR spectroscopy
Hyperpolarization with parahydrogen in NMR
Hyperpolarization-enhanced NMR spectroscopy of unaltered biofluids using photo-CIDNP
Photo-CIDNP MAS NMR : generation, transfer and application of nuclear hyperpolarization
Pulsed control methods with applications to nuclear hyperpolarization and nanoscale NMR
13 C and 15 N Benchtop NMR Detection of Metabolites via Relayed Hyperpolarization **
NMR sensitivity enhancement of functional biomolecules : design and development of PHIP-based hyperpolarization approaches
Parahydrogen Hyperpolarization Allows Direct NMR Detection of α‐Amino Acids in Complex (Bio)mixtures
Parahydrogen Hyperpolarization Allows Direct NMR Detection of α‐Amino Acids in Complex (Bio)mixtures
NMR in target driven drug discovery: why not?
Fragment Screening and Fast Micromolar Detection on a Benchtop NMR Spectrometer Boosted by Photoinduced Hyperpolarization