Enzymatic Oxy‐ and Amino‐Functionalization in Biocatalytic Cascade Synthesis: Recent Advances and Future Perspectives
Abstract: Biocatalytic cascades are a powerful tool for building complex molecules containing oxygen and nitrogen functionalities. Moreover, the combination of multiple enzymes in one pot offers the possibility to minimize downstream processing and waste production. In this review, we illustrate various recent efforts in the development of multi‐step syntheses involving C−O and C−N bond‐forming enzymes to produce high value‐added compounds, such as pharmaceuticals and polymer precursors. Both in vitro and in vivo examples are discussed, revealing the respective advantages and drawbacks. The use of engineered enzymes to boost the cascades outcome is also addressed and current co‐substrate and cofactor recycling strategies are presented, highlighting the importance of atom economy. Finally, tools to overcome current challenges for multi‐enzymatic oxy‐ and amino‐functionalization reactions are discussed, including flow systems with immobilized biocatalysts and cascades in confined nanomaterials.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Enzymatic Oxy‐ and Amino‐Functionalization in Biocatalytic Cascade Synthesis: Recent Advances and Future Perspectives ; day:12 ; month:09 ; year:2023 ; extent:28
Angewandte Chemie / International edition. International edition ; (12.09.2023) (gesamt 28)
- Urheber
- DOI
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10.1002/anie.202309012
- URN
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urn:nbn:de:101:1-2023091315163364838239
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 14.08.2025, 11:01 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Grandi, Eleonora
- Feyza Özgen, Fatma
- Schmidt, Sandy
- Poelarends, Gerrit
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