A SLM2 feedback pathway controls cortical network activity and mouse behavior

Abstract: The brain is made up of trillions of synaptic connections that together form neural networks needed for normal brain function and behavior. SLM2 is a member of a conserved family of RNA binding proteins, including Sam68 and SLM1, that control splicing of Neurexin1-3 pre-mRNAs. Whether SLM2 affects neural network activity is unknown. Here, we find that SLM2 levels are maintained by a homeostatic feedback control pathway that predates the divergence of SLM2 and Sam68. SLM2 also controls the splicing of Tomosyn2, LysoPLD/ATX, Dgkb, Kif21a, and Cask, each of which are important for synapse function. Cortical neural network activity dependent on synaptic connections between SLM2-expressing-pyramidal neurons and interneurons is decreased in Slm2-null mice. Additionally, these mice are anxious and have a decreased ability to recognize novel objects. Our data reveal a pathway of SLM2 homeostatic auto-regulation controlling brain network activity and behavior

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Cell reports. - 17, 12 (2016) , 3269-3280, ISSN: 2211-1247

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2025
• Creator: Ehrmann, Ingrid ; Gazzara, Matthew R. ; Pagliarini, Vittoria ; Dalgliesh, Caroline ; Kheirollahi-Chadegani, Mahsa ; Xu, Yaobo ; Cesari, Eleonora ; Danilenko, Marina ; Maclennan, Marie ; Lowdon, Kate ; Vogel, Tanja ; Keskivali-Bond, Piia ; Wells, Sara ; Cater, Heather ; Fort, Philippe ; Santibanez-Koref, Mauro ; Middei, Silvia ; Sette, Claudio ; Clowry, Gavin J. ; Barash, Yoseph ; Cunningham, Mark O. ; Elliott, David J.

Further information

• DOI: 10.1016/j.celrep.2016.12.002
• URN: urn:nbn:de:bsz:25-freidok-1357938
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:31 AM CEST