Molecular Rotors: Fluorescent Sensors for Microviscosity and Conformation of Biomolecules
Abstract: The viscosity and crowding of biological environment are considered vital for the correct cellular function, and alterations in these parameters are known to underly a number of pathologies including diabetes, malaria, cancer and neurodegenerative diseases, to name a few. Over the last decades, fluorescent molecular probes termed molecular rotors proved extremely useful for exploring viscosity, crowding, and underlying molecular interactions in biologically relevant settings. In this review, we will discuss the basic principles underpinning the functionality of these probes and will review advances in their use as sensors for lipid order, protein crowding and conformation, temperature and non‐canonical nucleic acid structures in live cells and other relevant biological settings.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Molecular Rotors: Fluorescent Sensors for Microviscosity and Conformation of Biomolecules ; day:14 ; month:11 ; year:2023 ; extent:18
Angewandte Chemie / International edition. International edition ; (14.11.2023) (gesamt 18)
- Urheber
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Paez‐Perez, Miguel
Kuimova, Marina K.
- DOI
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10.1002/anie.202311233
- URN
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urn:nbn:de:101:1-2023111514063005417257
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 14.08.2025, 10:44 MESZ
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Beteiligte
- Paez‐Perez, Miguel
- Kuimova, Marina K.
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