Dietary Amino Acid Source Elicits Sex‐Specific Metabolic Response to Diet‐Induced NAFLD in Mice

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Scope: Non‐alcoholic fatty liver disease (NAFLD) is a sexually dimorphic disease influenced by dietary factors. Here, the metabolic and hepatic effects of dietary amino acid (AA) source is assessed in Western diet (WD)‐induced NAFLD in male and female mice. Methods and results: The AA source is either casein or a free AA mixture mimicking the composition of casein. As expected, males fed a casein‐based WD display glucose intolerance, fasting hyperglycemia, and insulin‐resistance and develop NAFLD associated with changes in hepatic gene expression and microbiota dysbiosis. In contrast, males fed the AA‐based WD show no steatosis, a similar gene expression profile as males fed a control diet, and a distinct microbiota composition compared to males fed a casein‐based WD. Females are protected against WD‐induced liver damage, hepatic gene expression, and gut microbiota changes regardless of the AA source. Conclusions: Free dietary AA intake prevents the unhealthy metabolic outcomes of a WD preferentially in male mice.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Dietary Amino Acid Source Elicits Sex‐Specific Metabolic Response to Diet‐Induced NAFLD in Mice ; day:27 ; month:10 ; year:2023 ; extent:15
Molecular nutrition & food research ; (27.10.2023) (gesamt 15)

Urheber
Rives, Clémence
Martin, Céline Marie Pauline
Evariste, Lauris
Polizzi, Arnaud
Huillet, Marine
Lasserre, Frédéric
Alquier‐Bacquie, Valérie
Perrier, Prunelle
Gomez, Jelskey
Lippi, Yannick
Naylies, Claire
Levade, Thierry
Sabourdy, Frédérique
Remignon, Hervé
Fafournoux, Pierre
Chassaing, Benoit
Loiseau, Nicolas
Guillou, Hervé
Ellero‐Simatos, Sandrine
Gamet‐Payrastre, Laurence
Fougerat, Anne

DOI
10.1002/mnfr.202300491
URN
urn:nbn:de:101:1-2023102715244433443880
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
14.08.2025, 10:55 MESZ

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Beteiligte

  • Rives, Clémence
  • Martin, Céline Marie Pauline
  • Evariste, Lauris
  • Polizzi, Arnaud
  • Huillet, Marine
  • Lasserre, Frédéric
  • Alquier‐Bacquie, Valérie
  • Perrier, Prunelle
  • Gomez, Jelskey
  • Lippi, Yannick
  • Naylies, Claire
  • Levade, Thierry
  • Sabourdy, Frédérique
  • Remignon, Hervé
  • Fafournoux, Pierre
  • Chassaing, Benoit
  • Loiseau, Nicolas
  • Guillou, Hervé
  • Ellero‐Simatos, Sandrine
  • Gamet‐Payrastre, Laurence
  • Fougerat, Anne

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