Aquaporin-4 Expression in Meningioma Malignancy Progression
Abstract: Objectives The aim of the present study is to analyze if aquaporin-4 (AQP4) may also be a tumor progression marker for meningiomas. Methods This is an immunohistochemistry study realized at the Universidade de São Paulo, São Paulo, state of São Paulo, Brazil: frozen meningioma samples from 81 patients (57 females and 24 males, age range from 22 to 81 years old, average 56.5 ± 14.1 years old), including 57 meningiomas World Health Organization (WHO) grade I (GI); 19 grade II (GII), and 5 grade III (GIII) were analyzed. The relative expression level of AQP4 was analyzed by quantitative polymerase chain reaction (qPCR), using the SYBR Green approach and for staining detection. Tissue sections were routinely processed and subjected to antigen retrieval. Results The expression of AQP4 in meningioma samples ranged from 0 to 10.26, with a median of 0.001 in GI cases, of 0.008 in GII cases, and of 0.006 in GIII cases. Although not statistically significant (p = 0.942), GI meningiomas have a lower median AQP4 expression level than higher malignant grade cases. Conclusion The AQP4 gene and protein expressions presented no association with meningioma malignant progression.
- Weitere Titel
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Expressão da aquaporina-4 na progressão da malignidade dos meningiomas*
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Aquaporin-4 Expression in Meningioma Malignancy Progression ; day:07 ; month:11 ; year:2022
Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery ; (07.11.2022)
- Beteiligte Personen und Organisationen
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Pereira, Benedito Jamilson Araújo
Oba-Shinjo, Sueli M.
Aguiar, Paulo Henrique Pires de
Almeida, Antonio Nogueira de
Paiva, Wellingson da Silva
Marie, Suely Kazue Nagahashi
- DOI
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10.1055/s-0041-1731065
- URN
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urn:nbn:de:101:1-2022122910304740818078
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
- 15.08.2025, 05:31 UTC
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Pereira, Benedito Jamilson Araújo
- Oba-Shinjo, Sueli M.
- Aguiar, Paulo Henrique Pires de
- Almeida, Antonio Nogueira de
- Paiva, Wellingson da Silva
- Marie, Suely Kazue Nagahashi
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