Enantioselective Synthesis of Tropane Scaffolds by an Organocatalyzed 1,3‐Dipolar Cycloaddition of 3‐Oxidopyridinium Betaines and Dienamines

Abstract: Tropane alkaloids constitute a compound‐class which is structurally defined by a central 8‐azabicyclo[3.2.1]octane core. A diverse bioactivity profile combined with an unusual aza‐bridged bicyclic framework has made tropanes molecules‐of‐interest within organic chemistry. Enantioselective examples of (5+2) cycloadditions between 3‐oxidopyridinium betaines and olefins remain unexplored, despite 3‐oxidopyridinium betaines being useful reagents in organic synthesis. The first asymmetric (5+2) cycloaddition of 3‐oxidopyridinium betaines is reported, affording tropane derivatives in up to quantitative yield and with excellent control of peri‐, regio‐, diastereo‐, and enantioselectivity. The reactivity is enabled by dienamine‐activation of α,β‐unsaturated aldehydes combined with in situ formation of the pyridinium reaction‐partner. A simple N‐deprotection protocol allows for liberation of the tropane alkaloid motif, and synthetic elaborations of the cycloadducts demonstrate their synthetic utility to achieve highly diastereoselective modification around the bicyclic framework. DFT computations suggest a stepwise mechanism where regio‐ and stereoselectivity are defined during the first bond‐forming step in which the pyridinium dipole exerts critical conformational control over its dienamine partner. In the second bond‐forming step, a kinetic preference toward an initial (5+4) cycloadduct was identified; however, a lack of catalyst turn‐over, reversibility, and thermodynamic bias favoring a (5+2) cycloadduct rendered the reaction fully periselective.

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• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Enantioselective Synthesis of Tropane Scaffolds by an Organocatalyzed 1,3‐Dipolar Cycloaddition of 3‐Oxidopyridinium Betaines and Dienamines ; day:02 ; month:08 ; year:2023 ; extent:13 ; Chemistry - a European journal ; (02.08.2023) (gesamt 13)

Contributors, Places and Time

• Creator: Lamhauge, Johannes N. ; McLeod, David A. ; Barløse, Casper L. ; Oliver, Gwyndaf Alun ; Viborg, Laura ; Warburg, Tobias ; Anker Jørgensen, Karl

Further information

• DOI: 10.1002/chem.202301830
• URN: urn:nbn:de:101:1-2023080315064966142424
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.