Efficacy and Safety of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor Use during Ramadan Fasting: A Systematic Review

Abstract: Background Religious intermittent fasting for 30 days during Ramadan may increase the risk of dehydration, hypovolemia, and hypoglycemia. These events may also be encountered when using sodium-glucose cotransporter 2 inhibitors (SGLT2is). Objectives This article evaluates the safety of the SGLT2 inhibitors in people with type 2 diabetes during Ramadan. Search Methods We searched PubMed CENTRAL, MEDLINE, and Google Scholar on July 25, 2023 without language restrictions. Selection Criteria All trials assessing the safety of SGLT2 inhibitors during Ramadan were assessed and summarized into preset points. Data Extraction Two authors independently extracted and reviewed the retrieved studies. A third author reviewed the merged summary of the two authors and modified the article when necessary. Results Diabetic ketoacidosis, hospitalization due to diabetes-related problems, and thrombosis were either not significantly related to SGLT2i use or not studied. Estimated glomerular filtration rate (eGFR) dropped significantly in one study; otherwise, it was either not statistically significant or not studied. Hypovolemia and dehydration were significantly increased in one study only. Conclusion From the available evidence, the use of SGLT2 inhibitors in people with diabetes during Ramadan seems to be safe and well tolerated. Hypovolemia and a drop in eGFR were reported in a few studies, with no reported clinical significance.

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• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Efficacy and Safety of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor Use during Ramadan Fasting: A Systematic Review ; volume:07 ; number:04 ; year:2024 ; pages:176-184 ; Journal of diabetes & endocrine practice ; 07, Heft 04 (2024), 176-184

Contributors, Places and Time

• Contributor: Abdelgadir, Elamin ; Bashier, Alaaeldin ; Ashfaq, Faryal ; Hassanein, Mohamed ; Beshyah, Salem

Further information

• DOI: 10.1055/s-0044-1791484
• URN: urn:nbn:de:101:1-2501231026393.427368472244
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.